Association of Enhanced Limbic Response to Threat With Decreased Cortical Facial Recognition Memory Response in Schizophrenia

Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
American Journal of Psychiatry (Impact Factor: 12.3). 03/2010; 167(4):418-26. DOI: 10.1176/appi.ajp.2009.09060808
Source: PubMed


Recognition memory of faces is impaired in patients with schizophrenia, as is the neural processing of threat-related signals, but how these deficits interact to produce symptoms is unclear. The authors used an affective face recognition paradigm to examine possible interactions between cognitive and affective neural systems in schizophrenia.
Blood-oxygen-level-dependent response was examined by means of functional magnetic resonance imaging (3 Tesla) in healthy comparison subjects (N=21) and in patients with schizophrenia (N=12) or schizoaffective disorder, depressed type (N=4), during a two-choice recognition task that used images of human faces. Each target face, previously displayed with a threatening or nonthreatening affect, was displayed with neutral affect. Responses to successful recognition and responses to the effect of previously threatening versus nonthreatening affect were evaluated, and correlations with symptom severity (total Brief Psychiatric Rating Scale score) were examined. Functional connectivity analyses examined the relationship between activation in the amygdala and cortical regions involved in recognition memory.
Patients performed the task more slowly than healthy comparison subjects. Comparison subjects recruited the expected cortical regions to a greater degree than patients, and patients with more severe symptoms demonstrated proportionally less recruitment. Increased symptoms were also correlated with augmented amygdala and orbitofrontal cortex response to threatening faces. Comparison subjects exhibited a negative correlation between activity in the amygdala and cortical regions involved in cognition, while patients showed weakening of this relationship.
Increased symptoms were related to an enhanced threat response in limbic regions and a diminished recognition memory response in cortical regions, supporting a link between these two brain systems that are often examined in isolation. This finding suggests that abnormal processing of threat-related signals in the environment may exacerbate cognitive impairment in schizophrenia.

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Available from: Jeffrey N Valdez, Oct 06, 2015
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    • "It also influences the endocrine system and the autonomic nervous system. Damage to the limbic system causes many neuropsychiatric disorders including anxiety disorder, bipolar (affective) disorder, psychopathic disorders, amnestic disorders, schizophrenia, and dementias (84, 85). The basal ganglia system is a group of nuclei located near the thalamus and hypothalamus. "
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    • "Satterthwaite et al. (2010) examined the interaction between limbic regions involved in emotion processing and parietal regions involved in “recognition memory” in a task in which subjects were asked to recognize neutral faces that were previously presented (“was this face presented before?”). Patients exhibited a different pattern than healthy subjects, with an increased connectivity (correlation) among amygdala and other limbic areas, and an increased connectivity (in a form of a diminished negative correlation) between amygdala and cortical regions. "
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