Low physical activity is associated with proinflammatory high‐density lipoprotein and increased subclinical atherosclerosis in women with systemic lupus erythematosus

David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1670, USA.
Arthritis care & research 02/2010; 62(2):258-65. DOI: 10.1002/acr.20076
Source: PubMed


To investigate the association between physical activity, functional activity of high-density lipoprotein (HDL), and subclinical cardiovascular disease in patients with systemic lupus erythematosus (SLE).
A total of 242 SLE patients (all women) participated in this cross-sectional study from February 2004 to February 2008. Carotid plaque and intima-media thickness (IMT), antioxidant function of HDL, and traditional cardiac risk factors were measured. Physical activity was assessed from self-reports by calculating the metabolic equivalents (METS) per week and by the physical function domain of the Medical Outcomes Study Short Form 36 (SF-36). Data were analyzed using bivariate and multivariate regression analyses.
Number of METS per week spent performing strenuous exercise was negatively correlated with IMT (r = -0.4, P = 0.002) and number of plaques (r = -0.30, P = 0.0001). Physical function as assessed by the SF-36 was also negatively correlated with IMT (r = -0.14, P = 0.03) and number of plaques (r = -0.14, P = 0.04). In multivariate analyses, number of strenuous exercise METS was significantly associated with IMT (t = -2.2, P = 0.028) and number of plaques (t = -2.5, P = 0.014) when controlling for markers of SLE disease activity and damage, but not after controlling for traditional cardiac risk factors. Low physical activity, defined as <225 total METS per week, was associated with the presence of proinflammatory HDL (P = 0.03).
Low physical activity is associated with increased subclinical atherosclerosis and proinflammatory HDL in patients with SLE. Increased strenuous exercise may reduce the risk of atherosclerosis in SLE.

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    • "Although physical activity reduces the patients' fear of disability, there is still a great difference of opinion about the time of onset, type and intensity of that activity. Knowing the physiology of physical activity will be reasonable to apply it during treatment or as an early prevention of the disease's sequelae (Krupp et al. 1991; Gustafsson et al. 2009; Volkmann et al. 2010). It is unknown which type and intensity of physical activity contributes most to the treatment. "
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    ABSTRACT: Given the crucial events in systemic lupus erythematosus (SLE) such as joint and muscle pain, fatigue, depression, obesity and osteoporosis, the very thought of exercising can be challenging. This prospective study included 60 patients diagnosed with SLE in stable condition. A randomly selected group of 30 women had aerobic training on a bicycle ergometer for a period of 15 minutes, 3 times per week for 6 weeks, while the second group of 30 women performed isotonic exercises (to stretch and lengthen muscles and improve the range of motion) for 30 minutes, 3 times per week during the same period. Fatigue Severity Scale (FSS), Short Form 36 (SF36) questionnaire on the quality of life and Beck depression inventory (BDI) were analyzed at baseline and after 6 weeks. At baseline FSS score was 53.8 ± 5.7 and after the physical activity FSS score was 29.1 ± 7.8 (FSS ≥ 36; fatigue is present). The largest number of patients (66.7%) was in a moderate depressed state at the baseline, while after physical activities 61.7% of patients, had a mild mood disturbance. There were significant differences (p < 0.001) in values of all areas of quality of life questionnaire SF36 before and after the implementation of physical activity. The type of physical activity had no influence in FSS and BDI values. Continuous physical activity, regardless of its type, significantly improved quality of life of SLE patients. We recommend regular physical activity as an integral part of modern therapeutic approach in this patient population.
    The Tohoku Journal of Experimental Medicine 07/2015; 237(3):193-199. DOI:10.1620/tjem.237.193 · 1.35 Impact Factor
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    • "Although the relationship between physical activity and HDL was not addressed in this study, we can speculate that persistent active disease associated with physical incapacity due to functional impairment may play an important role in the dyslipidemic status that we observed in our JIA patients because a sedentary lifestyle is a contributing factor for decreased HDL. Moreover, decreased physical activity was recently associated with proinflammatory HDL in patients with SLE, which suggests that exercise can modulate the development of cardiovascular disease in this group of patients, possibly by decreasing inflammatory mediators.32 "
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