Article

Low physical activity is associated with proinflammatory high-density lipoprotein and increased subclinical atherosclerosis in women with systemic lupus erythematosus.

David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1670, USA.
Arthritis care & research 02/2010; 62(2):258-65. DOI: 10.1002/acr.20076
Source: PubMed

ABSTRACT To investigate the association between physical activity, functional activity of high-density lipoprotein (HDL), and subclinical cardiovascular disease in patients with systemic lupus erythematosus (SLE).
A total of 242 SLE patients (all women) participated in this cross-sectional study from February 2004 to February 2008. Carotid plaque and intima-media thickness (IMT), antioxidant function of HDL, and traditional cardiac risk factors were measured. Physical activity was assessed from self-reports by calculating the metabolic equivalents (METS) per week and by the physical function domain of the Medical Outcomes Study Short Form 36 (SF-36). Data were analyzed using bivariate and multivariate regression analyses.
Number of METS per week spent performing strenuous exercise was negatively correlated with IMT (r = -0.4, P = 0.002) and number of plaques (r = -0.30, P = 0.0001). Physical function as assessed by the SF-36 was also negatively correlated with IMT (r = -0.14, P = 0.03) and number of plaques (r = -0.14, P = 0.04). In multivariate analyses, number of strenuous exercise METS was significantly associated with IMT (t = -2.2, P = 0.028) and number of plaques (t = -2.5, P = 0.014) when controlling for markers of SLE disease activity and damage, but not after controlling for traditional cardiac risk factors. Low physical activity, defined as <225 total METS per week, was associated with the presence of proinflammatory HDL (P = 0.03).
Low physical activity is associated with increased subclinical atherosclerosis and proinflammatory HDL in patients with SLE. Increased strenuous exercise may reduce the risk of atherosclerosis in SLE.

Download full-text

Full-text

Available from: George A Karpouzas, Jul 28, 2015
0 Followers
 · 
112 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: This work is part of a large project called MIST (Materials Information for Science and Technology) to develop a prototype information system for materials science. In the future, this architecture is expected to provide the basis for a common interface to a network of quasi-autonomous databases. MacMIST, the interface to the database, uses standard Macintosh as well as application-specific paradigms. MIST provides not only raw data, but also extensive metadata, including a thesaurus and glossary, knowledge of class hierarchies, and summaries of what data is currently available. MacMIST supplements users' a priori knowledge of context and meaning by incorporating such metadata into the interface dynamically. Use of caching and embedded menus facilitates fast and efficient access
    System Sciences, 1989. Vol.IV: Emerging Technologies and Applications Track, Proceedings of the Twenty-Second Annual Hawaii International Conference on; 02/1989
  • [Show abstract] [Hide abstract]
    ABSTRACT: Die rheumatoide Arthritis (RA) und der systemische Lupus erythematodes (SLE) sind mit einer erhöhten Mortalität assoziiert, die hauptsächlich auf kardiovaskuläre Erkrankungen zurückzuführen ist. Das Risiko für einen Herzinfarkt ist bei RA-Betroffenen verdoppelt und bei SLE-Erkrankten sogar bis zu 7-fach erhöht.Neben den traditionellen Risikofaktoren hat eine chronische systemische Entzündung bedeutenden Einfluss auf die Entstehung der Arteriosklerose und die Progression von einer endothelialen Dysfunktion zur Plaqueruptur mit Thrombose. Zahlreiche Studien haben gezeigt, dass die Arteriosklerose keine alleinige, passive Lipidakkumulation in den Gefäßwänden darstellt, sondern durch einen aktiven Entzündungsprozess in den Gefäßwänden charakterisiert ist. Entzündungszellen wie Makrophagen, Monozyten und T-Zellen spielen sowohl bei der Entwicklung der RA als auch der Arteriosklerose eine entscheidende Rolle.Nach den Empfehlungen der EULAR sollen alle Patienten mit inflammatorischen Arthritiden ein jährliches Screening auf kardiovaskuläre Risikofaktoren erhalten. Alle Risikofaktoren sollten optimal eingestellt werden. Zudem gibt es genügend Evidenz, dass die entzündlichen systemischen und vaskulären Prozesse zur Reduktion des kardiovaskulären Risikos gleichzeitig reduziert werden sollten.
    Zeitschrift für Rheumatologie 01/2010; 69(8). DOI:10.1007/s00393-009-0585-5 · 0.46 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are associated with increased mortality, largely as a consequence of cardiovascular (CV) disease. Studies found relative risk ratios of 2 for myocardial infarction in RA and up to 7 for myocardial infarction in SLE patients.Beyond the traditional CV risk factors, chronic systemic inflammation has been shown to be a crucial factor in atherosclerosis development and progression from endothelial dysfunction to plaque rupture and thrombosis. Numerous studies have shown that atherosclerosis is not a passive process characterized by accumulation of lipids in the vessel walls, but rather represents active inflammation of the vasculature. Inflammatory cells such as macrophages, monocytes and T cells play an important role in the development of both RA and atherosclerosis.According to the recently published EULAR recommendations for CV risk screening and management in patients with inflammatory arthritis, annual CV risk assessment is recommended for all patients with RA. Any CV risk factors identified should be optimally managed. In addition to appropriate CV risk management, aggressive suppression of the inflammatory process is recommended to further lower CV risk.
    Zeitschrift für Rheumatologie 10/2010; 69(8):680-4, 686-8. · 0.46 Impact Factor
Show more