The purpose of this secondary data analysis was to describe the prevalence and treatment of anemia and test the impact of anemia on physical and psychosocial outcomes at baseline and following restorative care interventions. A total of 451 residents from 12 nursing homes participated in this study. The average age of the participants was 83.74 (SD = 8.24), the majority were female (79%), White (66%), and unmarried (90%). A total of 245 (54%) residents were anemic, and 66% were treated with at least one medication. Physical performance was worse in those with anemia, and those with anemia associated with chronic kidney disease had lower self-efficacy and outcome expectations for functional activities than those without anemia. There was no time by treatment interaction between those with and without anemia. The findings provide some additional support for the prevalence of anemia and suggest that those with anemia associated with chronic kidney disease are less motivated to engage in functional activities.
"Increased risk of fractures , cardiovascular events  , and mortality   5.5% of adults ≥20 years old in NHANES (USA)  6%-19% with inflammatory bowel disease (Sweden)  (Scandinavia)  7.1% of men and 8.8% of women in KNHANES (Korea)  9% in routine exercise treadmill testing (USA)  15% (new-onset) in those attending diabetes clinics (UK)  18.4% in type II diabetics (Italy)  Significant variation by race with lower Hb levels among elderly African Americans and a 3-fold higher prevalence of anemia compared with whites (USA)    Elderly 8.8% of community-dwelling women aged 70-80 years old (USA)  Poor physical performance ; poor performance and faster decline on cognitive tests ; increased risk of fracture , falls  , hospitalization, nursing home placement  , and mortality    ; decline in quality of life , cognitive function , activities of daily living , mobility  , and strength   10.3% of adults aged N60 years old from ENSANUT (Mexico)  11% of community-dwelling participants in NHANES (US)  29% of adults aged N60 years old in long-term care facilities (Brazil)  54% of residents from 12 nursing homes (USA)  27.6% in admissions with normal kidney function  Hospitalized 27.6% undergoing general surgery (Hb b12 g/dL)  Longer hospital stay; more resource utilization; increased risk of readmission, acute kidney injury, and death     One-third of nonsurgical cases  40.1% of nonsurgical hospitalized patients N60 years old  Hospital acquired anemia diagnosed in 74% of admissions  Ob/Gyn 5.5% of postmenopausal women (USA)   Anemia during pregnancy was associated with lower birth weight in 2 studies  , but not in another study  6.2% in first and 24.3% in third trimester (Belgium)  14.2%-16.7% during pregnancy (Hungary)  24.4% in 11 maternity units (UK)  39.6% from 14 cities (China)  43.7% and 89.8% in registries from the 1970s and 2000s, respectively (Kola, Russia)  Hb b10 and b8 g/dL seen in 22% and 3% of deliveries between 1993 and 2008 in an obstetrics department (Germany)  Increasing prevalence from first to third trimesters  CKD 32.3% in stage 3-5 CKD (anemia defined as Hb b11 g/dL or documented treatment of ESAs)  Increased risk of kidney disease progression, hospitalization, and death    41.3% in stage 3-5 CKD (defined as Hb 11-13.5 g/dL in men and Hb 11-12 g/dL in women)  45% in predialysis cases (defined as Hb ≤11 g/dL)  56.9% of nursing home residents with CKD  Respiratory disease Increased risk of hospitalization, readmission, and death      7.5%-34% in COPD  9.8%-33% in cases of acute exacerbation of COPD    11.5% in restrictive disease  13.3% in chronic respiratory failure  14.7% in obstructive disease  18% in first-time admissions to ICU requiring mechanical ventilation  33.9% at admission and 62.1% during stay for community-acquired pneumonia  Cerebrovascular disease 6.4%-19%    Increased risk of short-and long-term mortality and poor functional outcomes    IDA in 6.4%, iron deficiency without anemia in 2.1%, and anemia of other etiologies in 6.4% in patients aged N65 years old admitted with TIA or first ischemic stroke  Ischemic heart disease 9.1%-38% overall          Increased risk of cardiac events (including heart failure and recurrent ischemia); complications; poor health status; and in-hospital, short-and longterm death [149-157,159-164] 18.2% of patients aged N80 y admitted for acute MI  20%-27.4% at admission [159-161] 34.7% at discharge and 19.5% persistent during follow-up  40% at seventh week after admission  46.8% new-onset during admission  Hospital-acquired anemia seen at discharge in 45.4% of patients who were admitted with MI and normal Hb  Heart failure (hospitalized) 10% in chronic heart failure at age ≥70 y  Poor outcome, hospitalization, readmission, and mortality (cardiovascular as well as all cause) [165-177] 29%-57% [166-170] Cardiac surgery 28%-54.4% [178-180] Increased risk of receiving blood transfusions [179,180], major morbidity, acute kidney injury, mortality, prolonged hospital stay     , and cardiovascular events  41.9% of 80-to 90-year-old patients undergoing CPB  44% had sustained postoperative anemia for N50 d  Organ transplant 42%  and 53.7%  during posttransplant follow-up. "
[Show abstract][Hide abstract] ABSTRACT: Despite its high prevalence, anemia often does not receive proper clinical attention and its detection, evaluation, and management of iron deficiency anemia and iron-restricted erythropoiesis can possibly be an unmet medical need. A multidisciplinary panel of clinicians with expertise in anemia management convened and reviewed recent published data on prevalence, etiology, and health implications of anemia as well as current therapeutic options and available guidelines on management of anemia across various patient populations, and made recommendations on the detection, diagnostic approach and management of anemia. The available evidence confirms that the prevalence of anemia is high across all populations, especially in hospitalized patients. Anemia is associated with worse clinical outcomes including longer length of hospital stay, diminished quality of life and increased risk of morbidity and mortality, and it is a modifiable risk factor of allogeneic blood transfusion with its own inherent risks. Iron deficiency is usually present in anemic patients. An algorithm for detection and management of anemia was discussed which incorporated iron study (with primary emphasis on transferrin saturation), serum creatinine and GFR and vitamin B12 and folic acid measurements. Management strategies included iron therapy (oral or intravenous), erythropoiesis stimulating agents and referral as needed.
Transfusion medicine reviews 07/2014; 28(3). DOI:10.1016/j.tmrv.2014.05.001 · 2.92 Impact Factor
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