Article

Effects of phosphodiesterase-5 inhibitors on Leydig cell secretory function in oligoasthenospermic infertile men: a randomized trial.

Department of Urology, Tottori University School of Medicine, Yonago, Japan.
BJU International (impact factor: 2.84). 02/2010; 106(8):1181-5. DOI:10.1111/j.1464-410X.2010.09243.x pp.1181-5
Source: PubMed

ABSTRACT to evaluate the effects of phosphodiesterase-5 inhibitors (PDE5-i) on Leydig cell secretory function (LCSF).
in all, 75 men with oligoasthenospermia were treated daily for 12 weeks with either vardenafil (23 men, group A), sildenafil (25 men, group B) or l-carnitine (26 men, group C); a further group of 22 men with oligoasthenospermia (group D) received no treatment. Serum levels of insulin-like-3 peptide (INSL3) were evaluated before and after the end of the treatment in each of groups A, B and C, respectively. Serum INSL3 levels were measured in each participant of group D before and after the 12-week experimental period.
within group A and B, the peripheral serum mean INSL3 concentration, sperm concentration, percentage of motile spermatozoa, and percentage of morphologically normal spermatozoa were significantly greater after PDE5-i treatment than before.
we suggest that PDE5-i enhances LCSF, as the mean INSL3 concentration was significantly greater after PDE5-i administration than before, within groups A and B. This enhancement in LCSF might contribute to the increase in sperm concentration and sperm motility after administration of PDE5-i.

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Keywords

12-week experimental period
 
group A
 
group B
 
insulin-like-3 peptide
 
Leydig cell secretory function
 
mean INSL3 concentration
 
morphologically normal spermatozoa
 
motile spermatozoa
 
oligoasthenospermia
 
PDE5-i administration
 
PDE5-i enhances LCSF
 
PDE5-i treatment
 
peripheral serum
 
phosphodiesterase-5 inhibitors
 
Serum INSL3 levels
 
Serum levels
 
sildenafil
 
sperm concentration
 
sperm motility
 
vardenafil