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ABO Blood Group, Helicobacter pylori Seropositivity, and Risk of Pancreatic Cancer: A Case-Control Study

Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St, PO Box 208034, New Haven, CT 06520-8034, USA.
CancerSpectrum Knowledge Environment (Impact Factor: 15.16). 02/2010; 102(7):502-5. DOI: 10.1093/jnci/djq007
Source: PubMed

ABSTRACT Carriage of a non–O ABO blood group and colonization by Helicobacter pylori are thought to be risk factors for pancreatic cancer. We examined these associations in a population-based case–control study
of 373 case patients and 690 control subjects frequency matched on sex and age. Control subjects were selected by random-digit
dialing. Seropositivity for H pylori and its virulence protein CagA was determined by enzyme-linked immunosorbent assay (ELISA). Increased risk of pancreatic
cancer was associated with non–O blood group (adjusted odds ratio [OR] = 1.37, 95% confidence interval [CI] = 1.02 to 1.83,
P = .034) and CagA-negative H pylori seropositivity (OR = 1.68, 95% CI = 1.07 to 2.66, P = .025), but no association was observed for CagA seropositivity (OR = 0.77, 95% CI = 0.52 to 1.16). An association between
pancreatic cancer risk and CagA-negative H pylori seropositivity was found among individuals with non–O blood type but not among those with O blood type (OR = 2.78, 95% CI
= 1.49 to 5.20, P = .0014; OR = 1.28, 95% CI = 0.62 to 2.64, P = .51, respectively). This study demonstrates an association between pancreatic cancer and H pylori colonization, particularly for individuals with non–O blood types.

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    • "Compared with blood group O, individuals with non-O blood group (type A, AB, or B) were significantly more likely to develop pancreatic cancer (adjusted hazard ratio for incident pancreatic cancer 1.32, 1.51. and 1.72, respectively)(Wolpin et al., 2009, Risch et al., 2010), probably based on genetic variants in ABO locus 9q34 (Amundadottir et al, 2009). Another extended study identified susceptibility loci on 3 chromosomes-13q22.1, "
    Pancreatic Cancer - Molecular Mechanism and Targets, 12/2011; , ISBN: 978-953-51-0410-0
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    • "Decreased COMT activity with resultant higher dopamine is associated with lower risks of hypertension and myocardial infarction as is ABO blood group B compared to group A [57–63,67–70]. As expected, given ABO group B's increased risk of pancreatic cancer, low expression of COMT is associated with pancreatic cancer [71] [72] [73] [74] [75]. And consistent with ABO group B increased risk of DVT, low COMT has increased risk of DVT [76] [77] [78] [79]. "
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