Endothelial progenitor cells (EPCs) are responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Adipose tissue (AT) is an abundant source of mesenchymal stem cells (MSCs), which have multipotent differentiation ability. We successfully derived EPCs from AT, which maintained a strong proliferative capacity and demonstrated the characteristic endothelial function of uptaking of acetylated low-density lipoprotein. They formed tube-like structures in vitro. Endothelial nitric oxide synthase (eNOS) gene expression in EPCs was similar to that in mature endothelial cells. Transplantation of EPCs derived from AT after the acute phase was applied in rats with traumatic brain injury (TBI). Transplanted EPCs participated in the neovascularization of injured brain. Improving functional recovery, reducement of deficiency volume of brain, host astrogliosis and inflammation were found. These results suggest that adult AT derived stem cells can be induced to functional EPCs and have beneficial effect on cell therapy.
"ADSCs are easily obtained from minimally invasive liposuction . ADSCs can differentiate into fibroblasts , myoblasts , smooth muscle cells , endothelial cells , or skeletal muscle . They can express specific striated muscle markers (eg, desmin, myod1, myogenin, myosin heavy chain), form multinucleated cells characteristic of myotubules, and have been shown to regenerate the functional capacity of damaged skeletal muscle . "
[Show abstract][Hide abstract] ABSTRACT: Stress urinary incontinence (SUI) is highly prevalent. As of now, there is no minimally invasive long-term treatment available. Adult stem cells are nonimmunogenic and have the ability to self-renew and to differentiate into multiple cell types. Over the past decade, in vivo studies have described periurethral injections of adult-derived stem cells for the treatment of SUI. The ultimate goal has been to achieve a permanent cure for SUI by restoration of the intrinsic and extrinsic urethral sphincter and the surrounding connective tissue, including peripheral nerves and blood vessels. For this purpose, future studies need to focus on delivery systems, cell survival, and functional improvement of the urethral closure mechanism, including improvement of innervation and vascularization.
Current Urology Reports 02/2011; 12(1):41-6. DOI:10.1007/s11934-010-0155-z · 1.51 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: This paper presents a new logic-based method for online power
system fault diagnosis in a control center environment. The unique
feature of the approach is the use of sequence of events recorder
information from substations, together with data acquired by the energy
management system (EMS). A proposed line fault proof algorithm is
applied to a line if any protective device in the line's protection net
is triggered. The method has been validated through testing with fault
scenarios from the Italian power system
Intelligent Systems Applications to Power Systems, 1996. Proceedings, ISAP '96., International Conference on; 01/1996
[Show abstract][Hide abstract] ABSTRACT: Traumatic brain injury (TBI) is a major cause of mortality and morbidity in the world. Recent clinical investigations and basic researches suggest that strategies to improve angiogenesis following TBI may provide promising opportunities to improve clinical outcomes and brain functional recovery. More and more evidences show that circulating endothelial progenitor cells (EPCs), which have been identified in the peripheral blood, may play an important role in the pathologic and physiological angiogenesis in adults. Moreover, impressive data demonstrate that EPCs are mobilized from bone marrow to blood circulation in response to traumatic or inflammatory stimulations. In this review, we discussed the role of EPCs in the repair of brain injury and the possible therapeutic implication for functional recovery of TBI in the future.
Chinese Journal of Traumatology (English Edition) 10/2010; 13(5):316-8. DOI:10.3760/cma.j.issn.1008-1275.2010.05.013
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