Does D matter? The role of vitamin D in hair disorders and hair follicle cycling

Department of Dermatology, University of Texas and MD Anderson Cancer Center, Houston, Texas, USA.
Dermatology online journal 02/2010; 16(2):3.
Source: PubMed


The role of vitamin D in the proliferation and differentiation of keratinocytes is well known within the field of dermatology.
We sought to evaluate the role that vitamin D and the vitamin D receptor play in the hair cycle and assess how this can be clinically applied to the treatment of hair disorders.
A MEDLINE search (1955-July 2009) was preformed to find relevant articles pertaining to vitamin D, the vitamin D receptor, and hair loss.
The vitamin D receptor, independent of vitamin D, plays an important role in hair cycling, specifically anagen initiation. The role of vitamin D in hair follicle cycling is not as well understood.
The review is broad and there are limited human studies available to date.
Additional studies to evaluate the role of vitamin D in the hair cycle should be done. Treatments that up regulate the vitamin D receptor may be successful in treating hair disorders and are a potential area of further study.

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    • "Vitamin D is a steroid hormone that regulates several endocrine functions and cell functions such as, proliferation and differentiation. [8] [9]. The 1,25(OH) 2 D is one of potent regulators of cell growth and differentiation, which is an effect on cell death, tumor invasion, and angiogenesis, which makes it a candidate compound for cancer regulation [9]. "
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