Does D matter? The role of vitamin D in hair disorders and hair follicle cycling.
ABSTRACT The role of vitamin D in the proliferation and differentiation of keratinocytes is well known within the field of dermatology.
We sought to evaluate the role that vitamin D and the vitamin D receptor play in the hair cycle and assess how this can be clinically applied to the treatment of hair disorders.
A MEDLINE search (1955-July 2009) was preformed to find relevant articles pertaining to vitamin D, the vitamin D receptor, and hair loss.
The vitamin D receptor, independent of vitamin D, plays an important role in hair cycling, specifically anagen initiation. The role of vitamin D in hair follicle cycling is not as well understood.
The review is broad and there are limited human studies available to date.
Additional studies to evaluate the role of vitamin D in the hair cycle should be done. Treatments that up regulate the vitamin D receptor may be successful in treating hair disorders and are a potential area of further study.
SourceAvailable from: Rehab Hegazy[Show abstract] [Hide abstract]
ABSTRACT: The “sunshine” vitamin is a hot topic that attracted ample attention over the past decade, specially that a considerable proportion of the worldwide population are deficient in this essential nutrient. Vitamin D was primarily acknowledged for its importance in bone formation, however; increasing evidence point to its interference with the proper function of nearly every tissue in our bodies including brain, heart, muscles, immune system and skin. Thereby its deficiency has been incriminated in a long panel of diseases including cancers, autoimmune diseases, cardiovascular and neurological disorders. Its involvement in the pathogenesis of different dermatological diseases is no exception and has been the subject of much research over the recent years. In the current review, we will throw light on this highly disputed vitamin that is creating a significant concern from a dermatological perspective. Furthermore, the consequences of its deficiency on the skin will be in focus.Journal of Advanced Research 02/2014; DOI:10.1016/j.jare.2014.01.011
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ABSTRACT: Female pattern hair loss (FPHL) is the most common cause of hair loss in women. It has a greater psychosocial morbidity than that of male pattern hair loss. The clinical presentation of FPHL is distinctive with hair thinning usually confined to the crown region of the scalp. The frontal hair line is usually spared; however, it can be affected in some patients. Miniaturization of terminal scalp hair and shortening of the anagen growth phase of the hair cycle results in growth of thinner and shorter hair fibers. Diagnosis is usually made clinically. Recent advances in digital image analysis has increased the use of dermatoscopy in the diagnosis of FPHL and as a consequence, reduced the need for doing skin biopsies. Many medical and surgical treatments are currently available with various success rates. In this review article, we discuss the major recent advances in the diagnosis and management of FPHL.Expert Review of Dermatology 01/2014; 8(4). DOI:10.1586/17469872.2013.814858
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ABSTRACT: Objective. It has been stated that brain cancers are an increasingly serious issue in many parts of the world. The aim of our study was to determine a possible relationship between Vitamin D receptor (VDR) gene polymorphisms and the risk of glioma and meningioma. Methods. We investigated the VDR Taq-I and VDR Fok-I gene polymorphisms in 100 brain cancer patients (including 44 meningioma cases and 56 glioma cases) and 122 age-matched healthy control subjects. This study was performed by polymerase chain reaction-based restriction fragment length polymorphism (RF LP). Results. VDR Fok-I ff genotype was significantly increased in meningioma patients (15.9%) compared with controls (2.5%), and carriers of Fok-I ff genotype had a 6.47-fold increased risk for meningioma cases. There was no significant difference between patients and controls for VDR Taq-I genotypes and alleles. Conclusions. We suggest that VDR Fok-I genotypes might affect the development of meningioma.04/2013; 2013:295791. DOI:10.1155/2013/295791