Article

Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum.

Center for Neuroscience Research, Children's National Medical Center, Washington, DC, USA.
Nature Neuroscience (Impact Factor: 14.98). 02/2010; 13(3):287-9. DOI: 10.1038/nn.2500
Source: PubMed

ABSTRACT We found that demyelinated axons formed functional glutamatergic synapses onto adult-born NG2(+) oligodendrocyte progenitor cells (OPCs) migrating from the subventricular zone after focal demyelination of adult mice corpus callosum. This glutamatergic input was substantially reduced compared with endogenous callosal OPCs 1 week after lesion and was lost on differentiation into oligodendrocytes. Therefore, axon-oligodendrocyte progenitor synapse formation is a transient and regulated step that occurs during remyelination of callosal axons.

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