Article

Double high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation for primary disseminated medulloblastoma: a report of 3 cases.

Departments of Neurosurgery, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
Journal of Pediatric Hematology/Oncology (impact factor: 1.16). 02/2010; 32(2):e70-4. DOI:10.1097/MPH.0b013e3181c46b92 pp.e70-4
Source: PubMed

ABSTRACT We performed double high-dose chemotherapy followed by peripheral blood stem cell transplantation (PBSCT) in 3 children with medulloblastoma and primary leptomeningial dissemination, including spinal metastasis. After resection of the main tumor mass, 30.6 Gy whole craniospinal radiation therapy and 4 or 5 courses of conventional chemotherapy with vincristine (1.5 mg/m), carboplatin (560 mg/m), ifosfamide (9000 mg/m), and etoposide (500 mg/m), and 2 courses of high-dose thiotepa (680 mg/m) and melphalan (240 mg/m) therapy with PBSCT were administered. Two patients with low erythroblastic leukemia viral oncogene homolog 2 (ERBB2) gene expression achieved long-term survival (41 mo and 40 mo) but the patient with high ERBB2 expression relapsed 9 months after the second PBSCT.

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Keywords

2 courses
 
30.6 Gy whole craniospinal radiation therapy
 
cell transplantation
 
ERBB2
 
ERBB2 expression relapsed 9 months
 
ifosfamide
 
long-term survival
 
low erythroblastic leukemia viral oncogene homolog 2
 
main tumor mass
 
patients
 
primary leptomeningial dissemination
 
second PBSCT
 
vincristine