Hydroxyapatite nanorods/poly(vinyl pyrolidone) composite nanofibers, arrays and three-dimensional fabrics: electrospun preparation and transformation to hydroxyapatite nanostructures.

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People's Republic of China.
Acta biomaterialia (Impact Factor: 5.68). 02/2010; 6(8):3013-20. DOI: 10.1016/j.actbio.2010.02.015
Source: PubMed

ABSTRACT Electrospinning has been recognized as an efficient technique for fabricating polymer nanofibrous biomaterials. However, the study of electrospun inorganic biomaterials with well-designed three-dimensional (3-D) structures is still limited and little reported. In this study hydroxyapatite (HAp) nanorods with an average diameter of approximately 7 nm and length of approximately 27 nm were synthesized through a simple precipitation method and used for the fabrication of inorganic/organic [poly(vinyl pyrolidone) (PVP)] composite nanofibers by electrospinning in ethanol solution. 3-D fabrics and aligned nanofiber arrays of the HAp nanorods/PVP composite were obtained as precursors. Thereafter, 3-D single phase HAp fabrics, tubular structures and aligned nanofiber arrays were obtained after thermal treatment of the corresponding composite precursors. Cytotoxicity experiments indicated that the HAp fabric scaffold had good biocompatibility. In vitro experiments showed that mesenchymal stem cells could attach to the HAp fabric scaffold after culture for 24h.

  • Stem-Cell Nanoengineering, 1 edited by H. Baharvand, N. Aghdami, 01/2015: chapter 14: pages 243-263; John Wiley & Sons, Inc.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Flurbiprofen axetil (FA)-loaded coaxial electrospun poly(vinyl pyrrolidone) (PVP)–nanopoly(lactic-co-glycolic acid) core–shell composite nanofibers were successfully fabricated by a facile coaxial electrospinning, and an electrospun drug-loaded system was formed for anti-adhesion applications. The FA, which is a kind of lipid microsphere nonsteroidal anti-inflammatory drug, was shown to be successfully adsorbed in the PVP, and the formed poly(lactic-co-glycolic acid) (PLGA)/PVP/FA composite nanofibers exhibited a uniform and smooth morphology. The cell viability assay and cell morphology observation revealed that the formed PLGA/PVP/FA composite nanofibers were cytocompatible. Importantly, the loaded FA within the PLGA/PVP coaxial nanofibers showed a sustained-release profile and anti-adhesion activity to inhibit the growth of the IEC-6 and NIH3T3 model cells. With the significantly reduced burst-release profile, good cytocompatibility, and anti-adhesion activity, the developed PLGA/PVP/FA composite nanofibers were proposed to be a promising material in the fields of tissue engineering and pharmaceutical science. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41982.
    Journal of Applied Polymer Science 02/2015; 132(22). DOI:10.1002/app.41982 · 1.64 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Nanoscale three-dimensional (3D) scaffolds offer great promise for improved tissue integration and regeneration by their physical and chemical property enhancements. Electrospinning is a versatile bottom-up technique for producing porous 3D nanofibrous scaffolds that could closely mimic the structure of extracellular matrix. Much work has been committed to the development of this process through the years, and the resultant nanostructures have been subjugated to a wide range of applications in the field of bioengineering. In particular, the application of ceramic nanofibres in hard tissue engineering, such as dental and bone regeneration, is of increased research interest. This mini-review provides a brief overview of the bioceramic nanofibre scaffolds fabricated by electrospinning and highlights some of the significant process developments over recent years with their probable future trends and potential applications as biomedical implants.
    08/2014; 2(3):221-239. DOI:10.3390/fib2030221


Available from
Jun 3, 2014