Hydroxyapatite nanorods/poly(vinyl pyrolidone) composite nanofibers, arrays and three-dimensional fabrics: electrospun preparation and transformation to hydroxyapatite nanostructures.

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People's Republic of China.
Acta biomaterialia (Impact Factor: 5.68). 02/2010; 6(8):3013-20. DOI: 10.1016/j.actbio.2010.02.015
Source: PubMed

ABSTRACT Electrospinning has been recognized as an efficient technique for fabricating polymer nanofibrous biomaterials. However, the study of electrospun inorganic biomaterials with well-designed three-dimensional (3-D) structures is still limited and little reported. In this study hydroxyapatite (HAp) nanorods with an average diameter of approximately 7 nm and length of approximately 27 nm were synthesized through a simple precipitation method and used for the fabrication of inorganic/organic [poly(vinyl pyrolidone) (PVP)] composite nanofibers by electrospinning in ethanol solution. 3-D fabrics and aligned nanofiber arrays of the HAp nanorods/PVP composite were obtained as precursors. Thereafter, 3-D single phase HAp fabrics, tubular structures and aligned nanofiber arrays were obtained after thermal treatment of the corresponding composite precursors. Cytotoxicity experiments indicated that the HAp fabric scaffold had good biocompatibility. In vitro experiments showed that mesenchymal stem cells could attach to the HAp fabric scaffold after culture for 24h.

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    ABSTRACT: Nanostructured hydroxyapatite (n-HAp) with tuneable morphology was successfully synthesized by varying the process parameters using a hydrothermal process with CTAB and PEG as surfactants. Systematic experiments were carried out to investigate the influences of process parameters on morphology. The morphology of n-HAp can be modified from nanorods to spheres by replacing the surfactant CTAB with PEG. The prepared materials were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and field emission scanning electron microscopy (FESEM). The specific surface area (SSA) and pore size were determined by N2 adsorption–desorption isotherms. The obtained specific surface area of the nanorods is greater compared to the nanospheres of HAp. These nanostructures of HAp have been used for removal of Pb(II) ions from waste water. The kinetic mechanism was best described by a pseudo-second order model and the isotherm data were fitted well by the Langmuir isotherm and Freundlich model. The adsorption of Pb(II) was found to be 714.14 and 526.31 mg g-1 for the HAp nanorods and nanospheres respectively. The effect of pH, contact time and initial concentration of Pb(II) were also studied through batch experiments.
    RSC Advances 08/2014; 4(70):37446-37457. DOI:10.1039/c4ra06929c · 3.71 Impact Factor
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    ABSTRACT: Nanoscale three-dimensional (3D) scaffolds offer great promise for improved tissue integration and regeneration by their physical and chemical property enhancements. Electrospinning is a versatile bottom-up technique for producing porous 3D nanofibrous scaffolds that could closely mimic the structure of extracellular matrix. Much work has been committed to the development of this process through the years, and the resultant nanostructures have been subjugated to a wide range of applications in the field of bioengineering. In particular, the application of ceramic nanofibres in hard tissue engineering, such as dental and bone regeneration, is of increased research interest. This mini-review provides a brief overview of the bioceramic nanofibre scaffolds fabricated by electrospinning and highlights some of the significant process developments over recent years with their probable future trends and potential applications as biomedical implants.
    08/2014; 2(3):221-239. DOI:10.3390/fib2030221
  • Stem-Cell Nanoengineering, 1 edited by H. Baharvand, N. Aghdami, 01/2015: chapter 14: pages 243-263; John Wiley & Sons, Inc.


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Jun 3, 2014