Article

Different bacterial pathogens, different strategies, yet the aim is the same: evasion of intestinal dendritic cell recognition.

Department of Microbiology and Immunology, University of Melbourne, Gate 11, Royal Parade, Parkville 3010, Victoria, Australia. E-mail address:
The Journal of Immunology (Impact Factor: 5.36). 03/2010; 184(5):2237-42. DOI: 10.4049/jimmunol.0902871
Source: PubMed

ABSTRACT Given the central role of intestinal dendritic cells (DCs) in the regulation of gut immune responses, it is not surprising that several bacterial pathogens have evolved strategies to prevent or bypass recognition by DCs. In this article, we will review recent findings on the interaction between intestinal DCs and prototypical bacterial pathogens, such as Salmonella, Yersinia, or Helicobacter. We will discuss the different approaches with which these pathogens seek to evade DC recognition and subsequent T cell activation. These diverse strategies span to include mounting irrelevant immune responses, inhibition of Ag presentation by DCs, and stretch as far as to manipulate the Th1/Th2 balance of CD4(+) T cells in the bacteria's favor.

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