Article

Synergistic role of curcumin with current therapeutics in colorectal cancer: minireview.

Veterans Affairs Medical Center, Karmanos Cancer Institute, Department of Internal Medicine, Wayne State University, Detroit, Michigan 48201, USA.
Nutrition and Cancer (Impact Factor: 2.47). 11/2009; 61(6):842-6. DOI: 10.1080/01635580903285106
Source: PubMed

ABSTRACT Despite the use of surgical resection and aggressive chemotherapy, nearly 50% of patients with colorectal carcinoma develop recurrent disease, highlighting the need for improved therapies. Curcumin (diferuloylmethane), the major active ingredient of turmeric (curcuma longa) with no discernable toxicity, has been shown to inhibit the growth of transformed cells and colon carcinogenesis at the initiation, promotion, and progression stages in carcinogen-induced rodent models. In a Phase I clinical trial, curcumin has been found to be extremely well tolerated and effective. In this review, we summarized the current status of our knowledge about the effectiveness of curcumin when given in combination with current chemotherapeutics such as 5-fluorouracil, oxaliplatin, and gemcitabine in treatment of gastrointestinal cancers with particular reference to colorectal cancer. Existing data suggest that curcumin in combination with chemotherapy is a superior strategy for treatment of gastrointestinal cancer.

0 Followers
 · 
167 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: Abstract Curcumin, an active natural compound in turmeric and curry, has been reported to exhibit anti-cancer effect. Cisplatin, carboplatin and oxaliplatin are used to treat various types of cancers. However, acquired resistance and toxicities are observed. Here, the addition of curcumin significantly increased cytotoxicity of the anti-cancer drugs on human colorectal cancer HT-29 cells, producing synergistic (cisplatin and carboplatin) and additivity (oxaliplatin) effects. Treatments in combination with curcumin resulted in a significantly increased induction of apoptosis and occurrence of G2/M arrest. Nuclear apoptosis-inducing factor (AIF), EndoG and NF-κB were elevated by anti-cancer drugs, suggesting the involvement of AIF and EndoG. The addition of curcumin suppressed nuclear AIF and EndoG and reversed anti-cancer drugs-induced NF-κB expression, suggesting the association of EndoG and NF-κB in curcumin-enhanced chemosensitivity. Therefore, the intake of foods rich in curcumin or curcumin-containing supplements should be taken into consideration for patients receiving chemotherapy to optimize the outcome of treatments.
    International Journal of Food Sciences and Nutrition 01/2014; DOI:10.3109/09637486.2013.871694 · 1.20 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: This work introduces a new dimension for controlled drug delivery by nanofiber based scaffolds for anticancer therapy. The model anticancer drugs adopted in this work are curcumin and 5-fluorouracil (5-FU). Most of the drug loaded nanofibers synthesized thus far have failed to address the needs of personalized medication due to poor scalability of drug loading and delivery kinetics. This work opens up new avenues for circumventing such complications by altering the drug release profile by a simple one-step crosslinking reaction. With an aim to emphasize the role of polymer crosslinking in drug release kinetics, two variations of dual drug loaded core–shell nanofibers were synthesized with different extents of crosslinking and polymer composition. These two variations of drug loaded nanofibers exhibited contrasting 5-FU release profiles and thus manifested different therapeutic efficacy at different time points against A549 (Non-Small Cell Lung cancer) cells. The drug release profile of these fibers was further corroborated by different kinetic models to gain a perspective on the underlying mechanism driving the drug release from type I and type II nanofibers. The synergistic therapeutic potential of curcumin and 5-FU loaded core–shell nanofibers (type I and type II nanofibers) was also validated against A549 cells. As an outcome of this work, a clear correlation of cell viability with time lag in drug delivery in the case of type I and type II nanofibers could be drawn, which makes nanofiber based drug delivery even more flexible and therapeutically effective with minimal side effects.
    RSC Advances 08/2014; 4(72). DOI:10.1039/C4RA05001K · 3.71 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Colon cancer is one of the third most common cancer in man, the second most common cancer in women worldwide, and the second leading cause of mortality in the USA. There are a number of molecular pathways that have been implicated in colon carcinogenesis, including TGF-β/Smad signaling pathway. TGF-β (transforming growth factor-beta) signaling pathway has the potential to regulate various biological processes including cell growth, differentiation, apoptosis, extracellular matrix modeling, and immune response. TGF-β signaling pathway acts as a tumor suppressor, but alterations in TGF-β signaling pathway promotes colon cancer cell growth, migration, invasion, angiogenesis, and metastasis. Here we review the role of TGF-β signaling cascade in colon carcinogenesis and multiple molecular targets of curcumin in colon carcinogenesis. Elucidation of the molecular mechanism of curcumin on TGF-β signaling pathway-induced colon carcinogenesis may ultimately lead to novel and more effective treatments for colon cancer.
    Tumor Biology 03/2014; 35(8). DOI:10.1007/s13277-014-1840-1 · 2.84 Impact Factor

Full-text (2 Sources)

Download
153 Downloads
Available from
Jun 5, 2014