Performance monitoring and error significance in patients with obsessive-compulsive disorder.

Humboldt-Universität zu Berlin, Germany.
Biological psychology (Impact Factor: 4.36). 02/2010; 84(2):257-63. DOI: 10.1016/j.biopsycho.2010.02.002
Source: PubMed

ABSTRACT Performance monitoring has been consistently found to be overactive in obsessive-compulsive disorder (OCD). The present study examines whether performance monitoring in OCD is adjusted with error significance. Therefore, errors in a flanker task were followed by neutral (standard condition) or punishment feedbacks (punishment condition). In the standard condition patients had significantly larger error-related negativity (ERN) and correct-related negativity (CRN) ampliudes than controls. But, in the punishment condition groups did not differ in ERN and CRN amplitudes. While healthy controls showed an amplitude enhancement between standard and punishment condition, OCD patients showed no variation. In contrast, group differences were not found for the error positivity (Pe): both groups had larger Pe amplitudes in the punishment condition. Results confirm earlier findings of overactive error monitoring in OCD. The absence of a variation with error significance might indicate that OCD patients are unable to down-regulate their monitoring activity according to external requirements.

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    ABSTRACT: Obsessive-compulsive disorder (OCD) is characterized by overactivity in frontal and striatal brain regions, and event-related potential studies have shown increased brain activity during performance monitoring. The error-related negativity (ERN) is a component of the event-related potential that is observed following incorrect responses, and signals the need for behavioral adjustments. ERN enhancements have even been considered as a biomarker or endophenotype of OCD. However over the past years, enhanced ERN amplitudes, although less reliably, were also found in anxiety and affective disorders. These results question the specificity of ERN alterations to OCD. The present review summarizes current findings on performance monitoring and feedback processing in OCD and their relation to behavioral measures. Further, it discusses possible differential mechanisms contributing to amplitude variations in different clinical conditions.
    Neuroscience & Biobehavioral Reviews 04/2014; · 10.28 Impact Factor
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    NeuroImage: Clinical. 01/2014; 5.
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    ABSTRACT: Zusammenfassung. Die Zwangsstörung ist eine teilweise genetisch vermittelte psychische Störung, die mit neuropsychologischen Be-einträchtigungen einhergeht. Bisher war die Suche nach den genetischen Ursachen wenig erfolgreich, was an der polygenetischen Über-tragung und an der Heterogenität im klinischen Erscheinungsbild der Zwangsstörung liegen könnte. Die Verwendung des Endophäno-typenkonzepts kann möglicherweise dazu beitragen, diese Probleme zu reduzieren. Endophänotypen sind zustandsunabhängige Marker, die näher an den biologischen Ursachen einer Erkrankung liegen als der klinische Phänotyp und mit einem erhöhten genetischen Risiko für die Erkrankung einhergehen. Die im Bereich der Zwangsstörung existierenden Befunde zu Endophänotypen werden in dem vorlie-genden Artikel diskutiert und Implikationen für zukünftige Studien abgeleitet. Zusammenfassend lässt sich sagen, dass vielversprechende Kandidaten-Endophänotypen in den Bereichen Reaktionshemmung, Handlungsüberwachung und kognitive Flexibilität vorliegen. Abstract. Obsessive-compulsive disorder (OCD) is a heritable condition that is associated with neuropsychological deficits. However, genetic underpinnings are difficult to identify and results have been inconsistent. Reasons for this difficulty may be that multiple genes are involved in the etiology of OCD and that the clinical phenotype of OCD is heterogeneous. The use of cognitive and biological endo-phenotypes was suggested as a resolution to these problems. Endophenotypes are state independent markers that exhibit a closer relation with genetic underpinnings than the clinical phenotype itself. In the current review, we discuss the current state of research on candidate endophenotypes for OCD and consider implications and future directions. In conclusion, several promising candidate endophenotypes for OCD have been identified, namely response inhibition, performance monitoring, and cognitive flexibility.
    Zeitschrift für Psychiatrie Psychologie und Psychotherapie 01/2013; 61(3):155-165. · 1.99 Impact Factor


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Aug 17, 2014