Reward sensitivity: issues of measurement, and achieving consilience between human and animal phenotypes

Department of Psychology, University of Sussex, Falmer, Brighton BN1 9QG, UK.
Addiction Biology (Impact Factor: 5.93). 04/2010; 15(2):145-68. DOI: 10.1111/j.1369-1600.2009.00193.x
Source: PubMed

ABSTRACT Reward is a concept fundamental to discussions of drug abuse and addiction. The idea that altered sensitivity to either drug-reward, or to rewards in general, contributes to, or results from, drug-taking is a common theme in several theories of addiction. However, the concept of reward is problematic in that it is used to refer to apparently different behavioural phenomena, and even to diverse neurobiological processes (reward pathways). Whether these different phenomena are different behavioural expressions of a common underlying process is not established, and much research suggests that there may be only loose relationships among different aspects of reward. Measures of rewarding effects of drugs in humans often depend upon subjective reports. In animal studies, such insights are not available, and behavioural measures must be relied upon to infer rewarding effects of drugs or other events. In such animal studies, but also in many human methods established to objectify measures of reward, many other factors contribute to the behaviour being studied. For that reason, studying the biological (including genetic) bases of performance of tasks that ostensibly measure reward cannot provide unequivocal answers. The current overview outlines the strengths and weaknesses of current approaches that hinder the conciliation of cross-species studies of the genetics of reward sensitivity and the dysregulation of reward processes by drugs of abuse. Some suggestions are made as to how human and animal studies may be made to address more closely homologous behaviours, even if those processes are only partly able to isolate 'reward' from other factors contributing to behavioural output.

  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Evidence from both human and animal studies suggests that sensitivity to rewarding stimuli is positively associated with impulsive behaviors, including both impulsive decision making and inhibitory control. The current study examined associations between the hedonic value of a sweet taste and two forms of impulsivity (impulsive choice and impulsive action) in healthy young adults (N = 100). Participants completed a sweet taste test in which they rated their liking of various sweetness concentrations. Subjects also completed measures of impulsive choice (delay discounting), and impulsive action (go/no-go task). Subjects who discounted more steeply (i.e., greater impulsive choice) liked the high sweetness concentration solutions more. By contrast, sweet liking was not related to impulsive action. These findings indicate that impulsive choice may be associated with heightened sensitivity to the hedonic value of a rewarding stimulus, and that these constructs might share common underlying neurobiological mechanisms.
    Frontiers in Behavioral Neuroscience 06/2014; 8:228. DOI:10.3389/fnbeh.2014.00228 · 4.16 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: More than 76 million people world-wide are estimated to have diagnosable alcohol use disorders (AUDs) (alcohol abuse or dependence), making these disorders a major global health problem. Pharmacotherapy offers promising means for treating AUDs, and significant progress has been made in the past 20 years. The US Food and Drug Administration approved three of the four medications for alcoholism in the last two decades. Unfortunately, these medications do not work for everyone, prompting the need for a personalized approach to optimize clinical benefit or more efficacious medications that can treat a wider range of patients, or both. To promote global health, the potential reorganization of the National Institutes of Health (NIH) must continue to support the National Institute on Alcohol Abuse and Alcoholism's (NIAAA's) vision of ensuring the development and delivery of new and more efficacious medications to treat AUDs in the coming decade. To achieve this objective, the NIAAA Medications Development Team has identified three fundamental long-range goals: (1) to make the drug development process more efficient; (2) to identify more efficacious medications, personalize treatment approaches, or both; and (3) to facilitate the implementation and adaptation of medications in real-world treatment settings. These goals will be carried out through seven key objectives. This paper describes those objectives in terms of rationale and strategy. Successful implementation of these objectives will result in the development of more efficacious and safe medications, provide a greater selection of therapy options and ultimately lessen the impact of this devastating disorder.
    Addiction Biology 03/2012; 17(3):513-27. DOI:10.1111/j.1369-1600.2012.00454.x · 5.93 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Orgasm is assumed to be the height of sexual pleasure, reinforcing the recurrence of sexual behaviors. Surprisingly, data supporting the role of orgasm as a reward in women appear lacking. The most likely psychological function of orgasm in women, consistent with the very limited empirical information, is as a secondary reinforcer. In other words, sexual arousal is the primary reward for sexual behavior in women and orgasm associates sexual arousal with the partner. Data from a small (n = 38 women) pilot are presented to highlight the challenges of studying female orgasm. Challenges include differentiating vaginally- or clitorally-generated orgasms by self-report and the large proportion of women who are unsure if they experience orgasms. Finally, the recent spate of publications purporting to show differences in penile-vaginal intercourse induced orgasms is critiqued in light of the information reviewed.
    Sexual and Relationship Therapy 11/2011; 26(4):315-328. DOI:10.1080/14681994.2011.651452 · 0.51 Impact Factor