Article

[Identification of a new human leukocyte antigen A allele, HLA-A*3020].

Liaoning Blood Center, Shenyang, Liaoning, 110044 P.R.China.
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 02/2010; 27(1):96-9. DOI:10.3760/cma.j.issn.1003-9406.2010.01.021 pp.96-9
Source: PubMed

ABSTRACT To identify a novel human leukocyte antigen (HLA) A allele.
A new HLA-A allele was found during routine HLA genotyping by polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP) and sequencing-based typing (SBT).
The novel HLA-A*30 allele was identical to A*300101 except that a nucleotide C at position 294 of exon 2 is substituted by A, resulting in codon 98 changed from GAC (D) to GAA (E).
A new HLA allele, HLA-A*3020, was identified, and was named officially by the WHO Nomenclature Committee.

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Keywords

GAA
 
GAC
 
HLA
 
new HLA allele
 
new HLA-A allele
 
novel HLA-A*30 allele
 
novel human leukocyte antigen
 
nucleotide C
 
PCR-SSOP
 
polymerase chain reaction-sequence specific oligonucleotide probes
 
routine HLA genotyping
 
sequencing-based typing
 

Xiaofeng Li