Article

Epstein-Barr virus mimicking lymphoma on FDG-PET/CT.

Division of Nuclear Medicine, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA.
Clinical nuclear medicine (impact factor: 3.92). 12/2009; 34(12):891-3. DOI:10.1097/RLU.0b013e3181bed135 pp.891-3
Source: PubMed

ABSTRACT We report the case of a 17-year-old girl who presented with a several month history of fevers and abdominal pain. After cytomegalovirus (CMV) and Epstein-Barr virus (EBV) titers returned normal, FDG-PET/CT was obtained due to concern for lymphoma. FDG-PET/CT revealed a pattern of hypermetabolic activity in the adenoids, bilateral cervical lymph nodes, abdominal lymph nodes, and spleen, highly concerning for lymphoma. However, subsequent biopsy of a cervical lymph node revealed lymphadenitis consistent with EBV. This case highlights infection as the most well-known false-positive cause on FDG-PET, and how biopsy is essential to definitively distinguish malignancy from infection.

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Keywords

17-year-old girl
 
abdominal lymph nodes
 
adenoids
 
bilateral cervical lymph nodes
 
biopsy
 
cervical lymph node
 
cytomegalovirus
 
definitively distinguish malignancy
 
EBV
 
Epstein-Barr virus
 
FDG-PET/CT
 
hypermetabolic activity
 
lymphoma
 
month history
 
spleen
 
subsequent biopsy
 
well-known false-positive cause
 

Damita L Thomas