Contact dermatitis due to Centella asiatica

Department of Dermatology and Venereology, São Marcos Hospital, Braga, Portugal.
Contact Dermatitis (Impact Factor: 3.75). 01/2010; 62(1):54-5. DOI: 10.1111/j.1600-0536.2009.01651.x
Source: PubMed
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    • "Plant extracts are often considered safe [33], because of the simple fact that they come from nature [80]. On the other hand, irritation, contact allergic dermatitis, and other adverse reactions to natural products have been documented [55, 81]. "
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    ABSTRACT: The fact that the skin is the most visible organ makes us aware of the ageing process every minute. The use of plant extracts and herbs has its origins in ancient times. Chronological and photo-ageing can be easily distinguished clinically, but they share important molecular features. We tried to gather the most interesting evidence based on facts about plants and plant extracts used in antiaging products. Our main idea was to emphasize action mechanisms of these plant/herbal products, that is, their "strategies" in fighting skin ageing. Some of the plant extracts have the ability to scavenge free radicals, to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin. There are some plants that can affect skin elasticity and tightness. Certainly, there is a place for herbal principles in antiaging cosmetics. On the other hand, there is a constant need for more evaluation and more clinical studies in vivo with emphasis on the ingredient concentration of the plant/herbal products, its formulation, safety, and duration of the antiaging effect.
    Evidence-based Complementary and Alternative Medicine 01/2013; 2013(1):827248. DOI:10.1155/2013/827248 · 1.88 Impact Factor
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    • "Although C. asiatica is one of the top-selling herbal medicines due to its remarkable pharmacological effects, some precautions should be taken for this plant. It has been known to be safe when taken at the recommended doses; however, skin irritation and contact dermatitis have been reported in some cases [89–91]. In a very early paper in 1969 [92], the total saponoside fraction containing brahmic acid and its derivatives of the plant was stated to cause infertility in an experiment conducted on human and rat sperms. "
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    ABSTRACT: This paper covers the studies relevant to neuroprotective activity of Centella asiatica (L.) Urban, also known as "Gotu Kola." The plant is native to the Southeast Asia and has been used traditionally as brain tonic in ayurvedic medicine. The neuroprotective effect of C. asiatica has been searched using the key words "Centella, Centella asiatica, gotu kola, Asiatic pennywort, neuroprotection, and memory" through the electronic databases including Sciencedirect, Web of Science, Scopus, Pubmed, and Google Scholar. According to the literature survey, C. asiatica (gotu kola) has been reported to have a comprehensive neuroprotection by different modes of action such as enzyme inhibition, prevention of amyloid plaque formation in Alzheimer's disease, dopamine neurotoxicity in Parkinson's disease, and decreasing oxidative stress. Therefore, C. asiatica could be suggested to be a desired phytopharmaceutical with neuroprotective effect emerged from traditional medicine.
    Evidence-based Complementary and Alternative Medicine 05/2012; 2012(2):946259. DOI:10.1155/2012/946259 · 1.88 Impact Factor
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    ABSTRACT: Background: Plant materials are frequently used in cosmetic industry, including production of anti-aging products owing to the skin-nourishing and regenerating properties attributed to them, as well as to improve the final product's texture and scent. These ingredients, however, may cause allergic reactions, including contact allergy. The aim of this study was to analyze the composition of facial cosmetics with declared anti-aging actions for the presence of plant ingredients with known sensitizing potential. Materials and methods: We have analyzed 180 cosmetic products with declared anti-aging actions offered in wholesale outlets in Krakow and Lodz. Ingredients of the cosmetics, as stated on the product labels were analyzed according to INCI terminology. Based on European database Cosing, Internet database Cosmetic Analysis, as well as Environmental Working Group (EWG) Skin Deep Cosmetics Database, we have identified plant ingredients. They were further analyzed in terms of sensitizing potential known from literature, based on queries in bibliographic database PubMed and Scopus. Results: In the 180 cosmetics analyzed, we have identified 323 unique substances, among which there were 191 plant substances. Only 6 (3%) of 180 cosmetic product analyzed did not contain any plant material. Among the 191 identified plant ingredients, 29 (15%) were mentioned in medical literature as causes of allergic reaction. These sensitizing plant ingredients were present in 84 (47%) analyzed cosmetics. Conclusions: Every second cosmetic product with declared anti-aging properties includes plant substances with known sensitizing potential, most frequently citronellol, bisabolol and geraniol.Key words: plant ingredients, anti-aging products, sensitizing potential, contact allergy, allergic contact dermatitis
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