Contact dermatitis due to Centella asiatica.

Department of Dermatology and Venereology, São Marcos Hospital, Braga, Portugal.
Contact Dermatitis (Impact Factor: 3.62). 01/2010; 62(1):54-5. DOI: 10.1111/j.1600-0536.2009.01651.x
Source: PubMed
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    ABSTRACT: The fact that the skin is the most visible organ makes us aware of the ageing process every minute. The use of plant extracts and herbs has its origins in ancient times. Chronological and photo-ageing can be easily distinguished clinically, but they share important molecular features. We tried to gather the most interesting evidence based on facts about plants and plant extracts used in antiaging products. Our main idea was to emphasize action mechanisms of these plant/herbal products, that is, their "strategies" in fighting skin ageing. Some of the plant extracts have the ability to scavenge free radicals, to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin. There are some plants that can affect skin elasticity and tightness. Certainly, there is a place for herbal principles in antiaging cosmetics. On the other hand, there is a constant need for more evaluation and more clinical studies in vivo with emphasis on the ingredient concentration of the plant/herbal products, its formulation, safety, and duration of the antiaging effect.
    Evidence-based Complementary and Alternative Medicine 01/2013; 2013:827248. DOI:10.1155/2013/827248 · 2.18 Impact Factor
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    ABSTRACT: Background: Plant materials are frequently used in cosmetic industry, including production of anti-aging products owing to the skin-nourishing and regenerating properties attributed to them, as well as to improve the final product's texture and scent. These ingredients, however, may cause allergic reactions, including contact allergy. The aim of this study was to analyze the composition of facial cosmetics with declared anti-aging actions for the presence of plant ingredients with known sensitizing potential. Materials and methods: We have analyzed 180 cosmetic products with declared anti-aging actions offered in wholesale outlets in Krakow and Lodz. Ingredients of the cosmetics, as stated on the product labels were analyzed according to INCI terminology. Based on European database Cosing, Internet database Cosmetic Analysis, as well as Environmental Working Group (EWG) Skin Deep Cosmetics Database, we have identified plant ingredients. They were further analyzed in terms of sensitizing potential known from literature, based on queries in bibliographic database PubMed and Scopus. Results: In the 180 cosmetics analyzed, we have identified 323 unique substances, among which there were 191 plant substances. Only 6 (3%) of 180 cosmetic product analyzed did not contain any plant material. Among the 191 identified plant ingredients, 29 (15%) were mentioned in medical literature as causes of allergic reaction. These sensitizing plant ingredients were present in 84 (47%) analyzed cosmetics. Conclusions: Every second cosmetic product with declared anti-aging properties includes plant substances with known sensitizing potential, most frequently citronellol, bisabolol and geraniol.Key words: plant ingredients, anti-aging products, sensitizing potential, contact allergy, allergic contact dermatitis
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    ABSTRACT: The evidence on the safety of topical preparations containing botanical extracts is limited. To assess (i) the use of botanically derived compounds in a large population, (ii) the incidence of cutaneous side-effects, and (iii) the diagnostic usefulness of patch testing. A questionnaire was used in 2661 patients to assess both the prevalence and type of topical botanical preparations used, and the occurrence of adverse skin reactions. Patients declaring adverse reactions were patch tested with (i) the Italian (SIDAPA) baseline series, (ii) an additional botanical series, and (iii) the patients' own products. Of the patients, 1274 (48%) reported the use of topical botanical products; 139 patients (11%) commented on adverse cutaneous reactions; 75 (54%) showed positive reactions with the Italian baseline series. Among the 122 patients tested with the botanical series, 19 (16%) showed positive reactions, in many cases with concomitant relevant positivity to at least one allergen of the Italian series connected with cosmetics. The commonest botanically derived allergens were propolis, Compositae extracts, and Melaleuca alternifolia (tea tree) oil. Contact allergy is a possible adverse effect of natural products. Baseline series supplemented with the commonest botanical allergens may be adequate for detecting most of the cases of contact allergy to natural topical products.
    Contact Dermatitis 08/2013; 70(2). DOI:10.1111/cod.12124 · 3.62 Impact Factor