Copper-catalyzed direct alkynylation of electron-deficient polyfluoroarenes with terminal alkynes using O2 as an oxidant.
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China.Journal of the American Chemical Society (Impact Factor: 11.44). 03/2010; 132(8):2522-3. DOI: 10.1021/ja910461e
ABSTRACT A copper-catalyzed direct alkynylation of electron-deficient polyfluoroarenes with a wide range of terminal alkynes is realized for the first time. The reaction proceeds under mild conditions with O(2) as an oxidant.
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ABSTRACT: A copper-mediated C-S/N-S bond-forming reaction via C-H activation that uses elemental sulfur has been developed. The addition of TBAI was found to be crucial for the success of this transformation. The method is scalable, shows excellent functional group tolerance, and is compatible with heterocycle substrates, providing efficient and practical access to benzoisothiazolones. The direct diversification of the benzoisothiazolone products into a variety of sulfur-containing compounds is also demonstrated.Organic Letters 10/2014; · 6.32 Impact Factor
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