Copper-catalyzed direct alkynylation of electron-deficient polyfluoroarenes with terminal alkynes using O2 as an oxidant.
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China.Journal of the American Chemical Society (Impact Factor: 10.68). 03/2010; 132(8):2522-3. DOI:10.1021/ja910461e
ABSTRACT A copper-catalyzed direct alkynylation of electron-deficient polyfluoroarenes with a wide range of terminal alkynes is realized for the first time. The reaction proceeds under mild conditions with O(2) as an oxidant.
- Angewandte Chemie International Edition 09/2010; 49(40):7304-7. · 13.73 Impact Factor
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ABSTRACT: Hot alkyne! The in situ generation of Ethynyl-1,2-BenziodoXol-3(1H)-one (EBX) from the corresponding silyl protected reagent using TBAF is reported. EBX displayed exceptional acetylene transfer ability to stabilized enolates, even at –78 °C. The mild reaction conditions allowed the first ethynylation reactions of linear keto, cyano and nitro esters in high yields to give all-carbon quaternary centers or non-natural amino acids after selective reduction of the nitro group.Chemistry 08/2010; 16(31):9457-61. · 5.93 Impact Factor
- Angewandte Chemie International Edition 08/2010; 49(35):6174-7. · 13.73 Impact Factor
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