Zinc status and dietary quality of type 2 diabetic patients: implication of physical activity level.

Department of Food and Nutrition, Keimyung University, Daegu 704-701, Korea.
Nutrition research and practice (Impact Factor: 0.97). 01/2008; 2(1):41-5. DOI: 10.4162/nrp.2008.2.1.41
Source: PubMed

ABSTRACT The purpose of this study was to analyze the relationships among zinc status, diet quality, glycemic control and self-rated physical activity level of type 2 diabetic patients. Dietary intakes for two non-consecutive days were measured by 24-hour recall method for seventy-six diabetic patients. Fasting blood glucose and HbA1c were measured for the assessment of glycemic control. We evaluated the extent of dietary adequacy by the percentage of subjects with a dietary intake of a nutrient less than the estimated average requirement(EAR), the dietary diversity score(DDS) and the dietary variety score(DVS). Zinc status was assessed from serum levels and urinary excretion. Dietary inadequacy was serious for five nutrients: riboflavin, calcium, thiamin, zinc and vitamin C. Dietary intakes from the meat, fish, and egg food groups and the milk food group were below the recommended level. We found that subjects with high levels of physical activities had significantly higher DVS and serum zinc levels compared to others (p<0.05). Fasting blood glucose levels and HbA1c were not significantly different across self-reported physical activity levels. Therefore, we suggest that maintaining physical activity at or above a moderate level is beneficial to improving dietary quality and zinc status.

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    ABSTRACT: To evaluate the effect of zinc and other multi vitamin mineral supplementation on glycemic control and lipid profile in patients with type 2 diabetes mellitus. Diabetes patients (n=96) were randomly allocated to 3 groups; 29 subjects were supplemented with oral zinc sulfate (22 mg/day) and multivitamin mineral (zinc+MVM) preparation; 31 subjects were supplemented with the same preparation, without zinc (MVM) and 36 were given a matching placebo, for a period of 4 months in a single blinded study. Blood samples were taken at the baseline and after 4 months of supplementation, to assess blood glucose (fasting and post prandial) and glycosylated haemoglobin % (HbA1C%)levels. The Zinc+MVM group had a mean change of fasting blood sugar (FBS) -0.33 (SEM, 0.21) mmol/l and was significant (p =0.05) when compared with the other two groups (mean change in the MVM group +0.19 (0.31) and +0.43 (0.23) mmol/l in the control group respectively). When the baseline FBS was >5.56 (>100mg/dL) mmol/l, supplementation either with Zinc+MVM (p<0.001) or MVM (p=0.02) resulted in a significant favourable effect on blood glucose parameters. The HbA1C% level was lowered significantly irrespective of the baseline HbA1C% concentration, only in Zinc+MVM (p=0.01) supplemented individuals. In the other two groups, the change of HbA1C% level was not significant. Zinc supplementation with other multi vitamins daily to adult diabetes patients who had high baseline FBS levels demonstrated better glycemic control.
    Journal of Diabetology February. 01/2011; 1.
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    ABSTRACT: This study was carried out to determine whether a short-term zinc supplementation contributes to beneficial changes in glycemic control among type 2 diabetic patients. Seventy-six diabetic subjects and 72 normal adults participated in this study. Subjects were divided into supplemented and control groups. Forty-four diabetic patients and 34 normal subjects were supplemented with 50 mg zinc daily as zinc gluconate for 4 weeks. Zinc status was assessed from fasting plasma levels and urinary excretion. The effects of zinc supplementation on fasting blood glucose, HbA(1c), insulin, and C-peptide were measured at the beginning of the study and after 4 weeks of supplementation. The changes in glycemic control indicators were compared between diabetic groups, classified by baseline HbA(1c) levels, and by diabetic duration. At baseline, the incidence of marginal zinc deficiency in the diabetic group, as determined by plasma zinc level, was approximately twice as high as in the normal adult group. The changes of HbA(1c) concentration, and fasting blood glucose following supplementation were not statistically significant in diabetic subjects. In normal subjects, a significant decrease of HbA(1c) occurred only in the zinc supplemented group. No significant changes were observed for serum insulin and C-peptide in diabetic as well as normal subjects. However, when the changes were compared by baseline HbA(1c) level, we found that diabetic subjects with HbA(1c) >/= 7.5% showed significantly improved levels of HbA(1c) and fasting glucose after Zn supplementation. While such improvement in fasting blood glucose was significant among diabetics with shorter diabetic duration, significant levels of increase in serum insulin and C-peptide were observed in zinc supplemented subjects with longer diabetic duration. Fasting blood glucose was significantly decreased, whereas serum insulin and C-peptide were increased in diabetics with marginal zinc status. Therefore, we suggest that Zn supplementation for a short-term period may improve glycemic control in diabetic patients with higher HbA(1c) levels and marginal zinc status.
    Nutrition research and practice 01/2008; 2(4):283-8. · 0.97 Impact Factor


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