Conference Paper

Multi-wavelength NIR system for spectroscopy of biomedical tissues

Dept. of Electr. & Comput. Eng., Drexel Univ., Philadelphia, PA, USA;
DOI: 10.1109/MWP.2003.1422898 Conference: Microwave Photonics, 2003. MWP 2003 Proceedings. International Topical Meeting on
Source: IEEE Xplore

ABSTRACT A custom designed optical system is reported for tissue spectroscopy over four wavelengths of 677 nm, 780 nm, 830 nm, and 977 nm. A high speed laser driver is designed with a flat frequency response using pre-emphasis circuit. The driver is employed for high current in high power lasers. Phantom and intra-lipid experiments are performed to extract optical parameters of a turbid media. Broadband measurement is used to extract optical parameters of the phantom model simulating a breast tissue using forward scattering models. The optical parameters () are extracted with a very good accuracy.

0 Bookmarks
 · 
45 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Diffuse optical tomography (DOT) is a new tomographic technique, which is non-invasive and does not involve radiation exposure. In this paper, a self-developed near infrared (NIR) diffuse optical tomography instrument is described, and phantoms com-posed of Intra-lipids are discussed. The NIR optical characteristics of the homogenous Intra-lipid phantoms are measured to construct a set of databases at various concentrations, and further analysis using fitting curves is presented as well. Additionally, a pseudo-model technique for imitating biological tissues is proposed and implemented. This pseudo-model can be used to represent the same optical characteristics as real tissues, meaning that it is a viable alternative to cope with measuring limitations. Experiments reveal good results when the pseudo-model employs 1% Intra-lipid as a background tissue that imitates pork and 3% Intra-lipid as an inclusion to mimic a bone. Due to the limitations of hardware nowadays, obviously, this pseudo-model will offer a great aid for the development and evaluation of a DOT system.
    Journal- Chinese Institute of Engineers 03/2007; 30(2). · 0.21 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Broadband (30-1000MHz) frequency modulated spectroscopic measurements of brain tissue using near IR wavelengths are used for accurate extraction of absorption and scattering coefficients of cortex, CSF, and skull. Design of a helmet mounted untethered functional near IR system is presented in this paper that provides wireless communication between the monitoring and helmet mounted fNIR imaging sensors using high speed wireless ISM band Transmitter and UWB communication standards. Design specifications and predicted performance requirements are presented of the custom designed low power consuming optical transceivers and wireless communication subsystems using IBM 90nm CMOS foundry parameters.
    Microwave Symposium Digest (MTT), 2011 IEEE MTT-S International; 07/2011
  • [Show abstract] [Hide abstract]
    ABSTRACT: Microwave Photonics techniques are applied to functional near IR (fNIR) imaging systems, where absorption and scattering parameters of tissue is extracted using multi-wavelength spectroscopy. Clinical applications of fNIR systems to anesthesia and wound healing are also discussed.
    Conference Proceedings - Lasers and Electro-Optics Society Annual Meeting-LEOS 01/2009;