Article

Obesity Paradox and Cardiorespiratory Fitness in 12,417 Male Veterans Aged 40 to 70 Years

Department of Human Performance and Sport Sciences, Winston-Salem State University, 601 S Martin Luther King Jr Dr, Anderson C 24-E, Winston-Salem, NC 27110, USA.
Mayo Clinic Proceedings (Impact Factor: 5.81). 02/2010; 85(2):115-21. DOI: 10.4065/mcp.2009.0562
Source: PubMed

ABSTRACT To evaluate the influence of cardiorespiratory fitness (fitness) on the obesity paradox in middle-aged men with known or suspected coronary artery disease.
This study consists of 12,417 men aged 40 to 70 years (44% African American) who were referred for exercise testing at the Veterans Affairs Medical Centers in Washington, DC, or Palo Alto, CA (between January 1, 1983, and June 30, 2007). Fitness was quantified as metabolic equivalents achieved during a maximal exercise test and was categorized for analysis as low, moderate, and high (defined as <5, 5-10, and >10 metabolic equivalents, respectively). Adiposity was defined by body mass index (BMI) according to standard clinical guidelines. Separate and combined associations of fitness and adiposity with all-cause mortality were assessed by Cox proportional hazards analyses.
We recorded 2801 deaths during a mean+/-SD follow-up of 7.7+/-5.3 years. Multivariate hazard ratios (95% confidence interval) for all-cause mortality, with normal weight (BMI, 18.5-24.9 kg/m2) used as the reference group, were 1.9 (1.5-2.3), 0.7 (0.7-0.8), 0.7 (0.6-0.7), and 1.0 (0.8-1.1) for BMIs of less than 18.5, 25.0 to 29.9, 30.0 to 34.9, and 35.0 or more kg/m2, respectively. Compared with highly fit normal-weight men, underweight men with low fitness had the highest (4.5 [3.1-6.6]) and highly fit overweight men the lowest (0.4 [0.3-0.6]) mortality risk of any subgroup. Overweight and obese men with moderate fitness had mortality rates similar to those of the highly fit normal-weight reference group.
Fitness altered the obesity paradox. Overweight and obese men had increased longevity only if they registered high fitness.

0 Followers
 · 
127 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: OBJETIVO: conocer la autopercepción, satisfacción corporal, y cohesión social, de un grupo de niñas gimnastas de alto rendimiento, pertenecientes a un colegio particular de la ciudad de Temuco, Chile. MÉTODOS: investigación mixta de predominancia cualitativa del tipo exploratorio transeccional. El total de la muestra fue de 19 niñas, entre 8 y 13 años, integrantes de un equipo de gimnasia rítmica de alto rendimiento. Se utilizó el instrumento desarrollado por Cooper, Taylor, Cooper y Fairburn (1987), Body Shape Questionnaire (Cuestionario de la Figura Corporal), además de un sociograma, para conocer el estado de cohesión del grupo, y un test proyectivo, para conocer la auto-percepción corporal. RESULTADOS: se encontraron algunos casos de insatisfacción corporal, distorsión autoperceptiva y una baja cohesión grupal. CONCLUSIÓN: los resultados del estudio se condicen con otros desarrollados a nivel internacional, en donde deportes que destacan la estética física como un elemento importante, tienden a generar insatisfacción corporal y distorsión auto-perceptiva.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Overweight and obese individuals with type 2 diabetes are recommended to lose weight, but the associations between excess body weight and all-cause and cardiovascular mortality in patients with type 2 diabetes remain controversial. Therefore, we performed a dose-response meta-analysis to investigate this association. We searched PubMed and Embase through 19th October 2014 and examined the references of retrieved articles to identify relevant prospective cohort studies. A random-effect model was used to calculate the summary risk estimates. Nine studies including 13 cohorts with 161,984 participants were identified. The relative risks (RRs) of all-cause mortality in overweight and obese patients with type 2 diabetes were 0.81 (95 % confidence interval (CI) 0.74-0.90) and 0.72 (95 % CI 0.63-0.81) respectively, compared with the normal or non-overweight patients. Furthermore, a 5 kg/m(2) increase in body mass index was associated with a significantly reduced risk of all-cause mortality by 5 % (RR 0.95, 95 % CI 0.93-0.97). However, no significant association was found between obese and/or overweight and the risk of cardiovascular mortality in type 2 diabetic patients (RR 0.89; 95 % CI 0.66-1.20 for overweight and RR 0.77; 95 % CI 0.54-1.10 for obesity, respectively). The findings from the present meta-analysis indicate that excess body weight may be a protective factor for all-cause mortality among patients with type 2 diabetes.
    European Journal of Epidemiology 11/2014; 30(1). DOI:10.1007/s10654-014-9973-5 · 5.15 Impact Factor
  • Source

Full-text

Download
60 Downloads
Available from
Jun 2, 2014