Incidence of cancers, ischemic cardiovascular diseases and mortality during 5-year follow-up after stopping antioxidant vitamins and minerals supplements: A postintervention follow-up in the SU.VI.MAX Study

Unité de Recherche en Epidémiologie Nutritionnelle, UMR U557 INSERM, U 1125 INRA, CNAM, Université de Paris 13, Bobigny, France.
International Journal of Cancer (Impact Factor: 5.09). 10/2010; 127(8):1875-81. DOI: 10.1002/ijc.25201
Source: PubMed


The Supplementation in Vitamins and Mineral Antioxidants Study was a double-blind, placebo-controlled, randomized trial, in which 12,741 French adults (7,713 women aged 35-60 years and 5,028 men aged 45-60 years) received a combination of ascorbic acid (120 mg), vitamin E (30 mg), beta-carotene (6 mg), selenium (100 microg) and zinc (20 mg), or placebo daily for a median follow-up time of 7.5 years [October 1994 to September 2002]. Antioxidant supplementation decreased total cancer incidence and total mortality in men. Postintervention follow-up assessment of total cancer incidence, ischemic cardiovascular disease incidence and total mortality was carried out for 5 years [September 1, 2002, to September 1, 2007]. No late effect of antioxidant supplementation was revealed 5 years after ending the intervention neither on ischemic cardiovascular disease incidence and mortality in both genders nor on cancer incidence in women. Regarding duration of intervention effects in men, the reduced risk of total cancer incidence and total mortality was no longer evident after the 5-year postintervention follow-up. During the postsupplementation period, the relative risk (RR) for total cancer incidence (n = 126) was 0.98 (95% confidence interval [CI], 0.75-1.27) among antioxidant recipients compared to nonrecipients. For total mortality (n = 90), the RR was 0.98 (95% CI, 0.75-1.26) for men receiving antioxidants compared to nonrecipients. In conclusion, beneficial effects of antioxidant supplementation in men disappeared during postintervention follow-up.

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Available from: Emmanuelle Kesse-Guyot, Jun 10, 2015
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    • "Selenium plays a significant role in the prevention of the oxidative modification of lipids, reducing inflammation and preventing platelets from aggregating [12]. Its supplementation in patients with cardiovascular disease was found to lower the levels of total plasma cholesterol and low-density-lipoprotein (LDL) plasma cholesterol and doses as high as 300 mcg/day significantly increased HDL levels [13] [14] [15]. "
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    ABSTRACT: Accelerated oxidative damage is one of the hallmarks in both sickle cell disease (SCD) and thalassemia major (TM). A decreased antioxidant level is found in both diseases. Our study was carried out to evaluate the variation in serum levels of Selenium and vitamin E among a group of transfusion dependant Egyptian SCD and TM patients, further more to correlate these levels with iron overload status or transfusion requirements. A case-control study was conducted in the Cairo University Pediatric Hospital to assess the serum levels of Selenium using Atomic Absorption Spectrometer and vitamin E using commercially available ELISA Kit in transfusion dependent children, 30 with beta thalassemia and 30 with SCD in a steady state aged from 6 to 18 years, these findings were compared to 30 age/ sex matched healthy controls. Our results revealed a depleted antioxidants level in the studied group of Egyptian children with TM and SCD relative to healthy controls (P < 0.05). A significant positive correlation was found between vitamin E levels and ferritin (r=0.28, p=0.047) in SCD and TM patients. Non significant correlation was detected between serum Selenium and vitamin E. Moreover, values of these antioxidants did not correlate with indices of hemolysis nor with those of inflammation in chronically transfused TM and SCD patients.
    Journal of Advanced Research 01/2015; 135. DOI:10.1016/j.jare.2015.01.002
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    • "Although antioxidant therapy or prevention of various diseases is expected owing to the clinical importance of oxidative damage, antioxidants have been of limited therapeutic success (Steinhubl, 2008). Antioxidant supplements have exhibited little effect on preventing cancer, myocardial infarction and atherosclerosis, but rather conversely have increased mortality (Bjelakovic et al., 2007; Hackam, 2007; Brambilla et al., 2008; Steinhubl, 2008; Hercberg et al., 2010); thus, it is very important to be aware of side effects in developing an effective antioxidant for the prevention of oxidative stress-related diseases. Under these situations, an ideal antioxidant molecule is expected to mitigate excess oxidative stress, but not disturb the redox homeostasis. "
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    ABSTRACT: Molecular hydrogen (H2) has been accepted to be an inert and nonfunctional molecule in our body. We have turned this concept by demonstrating that H2 reacts with strong oxidants such as hydroxyl radical in cells, and proposed its potential for preventive and therapeutic applications. H2 has a number of advantages exhibiting extensive effects: H2 rapidly diffuses into tissues and cells, and it is mild enough neither to disturb metabolic redox reactions nor to affect signaling reactive oxygen species; therefore, there should be no or little adverse effects of H2. There are several methods to ingest or consume H2; inhaling H2 gas, drinking H2-dissolved water (H2-water), injecting H2-dissolved saline (H2-saline), taking an H2 bath, or dropping H2-saline into the eyes. The numerous publications on its biological and medical benefits revealed that H2 reduces oxidative stress not only by direct reactions with strong oxidants, but also indirectly by regulating various gene expressions. Moreover, by regulating the gene expressions, H2 functions as an anti-inflammatory and anti-apoptotic, and stimulates energy metabolism. In addition to growing evidence obtained by model animal experiments, extensive clinical examinations were performed or are under investigation. Since most drugs specifically act to their targets, H2 seems to differ from conventional pharmaceutical drugs. Owing to its great efficacy and lack of adverse effects, H2 has promising potential for clinical use against many diseases.
    Pharmacology [?] Therapeutics 04/2014; 144(1). DOI:10.1016/j.pharmthera.2014.04.006 · 9.72 Impact Factor
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    • "Dietary antioxidants play a key role in helping endogenous compounds to combat oxidative stress. They minimize the deleterious effects of free radicals and fight off tumors (Willcox et al., 2004; Donaldson, 2004; Hercberg et al., 2010; Riso et al., 2010; Myung et al, 2011). Vegetables, fruits, legumes, nuts, and seeds are sources of a variety of those bioactive compounds, such as carotenoids (including beta-carotene and lycopene), vitamin C, vitamin E, quercetin , and selenium. "
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    ABSTRACT: It is well known that oxidative stress is an inevitable event in aerobic life. When our cells use oxygen to create energy, a variety of reactive oxygen (ROS) and nitrogen species (RNS) are generated. These species could attack DNA directly and form mutagenic lesions afterwards. According to the oxidative stress hypothesis of aging, the oxidative damage to critical molecules accumulates over the life period and could ultimately impair the body’s function. Moreover, severe oxidative stress causes mutations of tumor suppressor genes, known as one of the initial events in carcinogenesis. Furthermore, it could also play a crucial role in the promotion of the multi-step carcinogenesis. On the other hand, the human body possesses a number of mechanisms that counteract oxidative stress by producing antioxidants in situ, or externally supplied them through foods and/or supplements. Indeed, a considerable amount of laboratory evidence from chemical, cell culture, and animal studies indicates that antioxidants may slow down or possibly prevent the cancer development. Yet, the information from recent cohort, case-control and/or ecological studies is less clear. Therefore, the objectives of this review are to compile a compendium of studies, and to identify effective and promising natural antioxidant interventions.
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