Article

Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium.

Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.
Cancer Research (impact factor: 7.86). 02/2010; 70(3):1015-23. DOI:10.1158/0008-5472.CAN-09-2993 pp.1015-23
Source: PubMed

ABSTRACT A recent genome-wide association study (PanScan) identified significant associations at the ABO gene locus with risk of pancreatic cancer, but the influence of specific ABO genotypes remains unknown. We determined ABO genotypes (OO, AO, AA, AB, BO, and BB) in 1,534 cases and 1,583 controls from 12 prospective cohorts in PanScan, grouping participants by genotype-derived serologic blood type (O, A, AB, and B). Adjusted odds ratios (ORs) for pancreatic cancer by ABO alleles were calculated using logistic regression. Compared with blood type O, the ORs for pancreatic cancer in subjects with types A, AB, and B were 1.38 [95% confidence interval (95% CI), 1.18-1.62], 1.47 (95% CI, 1.07-2.02), and 1.53 (95% CI, 1.21-1.92), respectively. The incidence rates for blood types O, A, AB, and B were 28.9, 39.9, 41.8, and 44.5 cases per 100,000 subjects per year. An increase in risk was noted with the addition of each non-O allele. Compared with OO genotype, subjects with AO and AA genotype had ORs of 1.33 (95% CI, 1.13-1.58) and 1.61 (95% CI, 1.22-2.18), whereas subjects with BO and BB genotypes had ORs of 1.45 (95% CI, 1.14-1.85) and 2.42 (1.28-4.57). The population attributable fraction for non-O blood type was 19.5%. In a joint model with smoking, current smokers with non-O blood type had an adjusted OR of 2.68 (95% CI, 2.03-3.54) compared with nonsmokers of blood type O. We concluded that ABO genotypes were significantly associated with pancreatic cancer risk.

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Keywords

12 prospective cohorts
 
ABO alleles
 
ABO gene locus
 
ABO genotypes
 
BB genotypes
 
blood type O
 
blood types O
 
current smokers
 
genotype-derived serologic blood type
 
grouping participants
 
joint model
 
non-O allele
 
non-O blood type
 
nonsmokers
 
pancreatic cancer
 
pancreatic cancer risk
 
population attributable fraction
 
recent genome-wide association study
 
significant associations
 
specific ABO genotypes