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Available from: Roger WIlliam Chapman, Oct 05, 2015
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    • ". The EASL and the AASLD guidelines recommend MR cholangiography as the first line imaging examination in patients with suspected PSC [34]. However, endoscopic retrograde cholangiography should still be performed when MR cholangiography is doubtful or inconclusive. "
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    ABSTRACT: Inflammatory bowel diseases (IBD) are associated with an increased risk of gastrointestinal cancers and more specifically in sites affected by chronic inflammation. However, patients with IBD have also an increased risk for developing a variety of extra-intestinal cancers. In this regard, hepatobiliary cancers, such as cholangiocarcinoma, are more frequently observed in IBD patients because of a high prevalence of primary sclerosing cholangitis, which is considered as a favoring condition. Extra-intestinal lymphomas, mostly non-Hodgkin lymphomas, and skin cancers are also observed with an increased incidence in IBD patients by comparison with that in patients without IBD. This review provides an update on demographics, risk factors and clinical features of extra-intestinal malignancies, including cholangiocarcinoma, hepatocellular carcinoma and lymphoma, that occur in patients with IBD along with a special emphasis on the multidetector row computed tomography and magnetic resonance imaging features of these uncommon conditions. Copyright © 2015 Éditions françaises de radiologie. Published by Elsevier Masson SAS. All rights reserved.
    Diagnostic and interventional imaging 04/2015; DOI:10.1016/j.diii.2015.02.009
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    • "Primary sclerosing cholangitis is a chronic cholestatic liver disease that causes inflammation, fibrosis, scarring, and destruction of the bile ducts at intrahepatic and extrahepatic levels (Cullen and Chapman 2003; Harrison and others 2005). The disease is a progressive immune-mediated disorder that culminates in cirrhosis, hepatic decompensation, and portal hypertension (Chapman and others 2010). About 70% of primary sclerosing cholangitis patients are young and middle-aged men (Mendes and Lindor 2010). "
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    ABSTRACT: Curcumin, the natural yellow-colored active principle, also called turmeric yellow, extracted from the perennial herb Curcuma longa L., has potent biological and pharmacological properties such as antioxidant, anti-inflammatory, antifungal, antibacterial, anti-ischemic, antitumor, and anticancer actions. The molecular mechanism of the hepatoprotective action of curcumin is due to its antioxidant properties and inhibitory activity against nuclear factor (NF)-B that regulates different proinflammatory and profibrotic cytokines. Overall, scientific reports demonstrate that curcumin has high therapeutic ability for treating hepatic disorders. Here is a systematic discussion of the hepatoprotective activity of curcumin and its possible mechanisms of actions.
    Comprehensive Reviews in Food Science and Food Safety 01/2014; 13(1). DOI:10.1111/1541-4337.12047 · 4.18 Impact Factor
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    • "Despite clinical trials of over fourteen different pharmacologic agents, including but not limited to various immunosuppressants and antifibrotics, medical therapy for PSC has yet to be established [2]. Unlike in other cholestatic liver diseases (e.g., primary biliary cirrhosis), treatment with ursodeoxycholic acid (UDCA) has not been clearly shown to have a beneficial effect in PSC [7]. In addition, high doses of UDCA may be associated with significantly greater incidence of adverse outcomes [8]. "
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    ABSTRACT: Primary sclerosing cholangitis (PSC) is an idiopathic, progressive, cholestatic liver disease with considerable morbidity and mortality and no established pharmacotherapy. In addition to the long-recognized association between PSC and inflammatory bowel disease, several lines of preclinical and clinical evidence implicate the microbiota in the etiopathogenesis of PSC. Here we provide a concise review of these data which, taken together, support further investigation of the role of the microbiota and antibiotics in PSC as potential avenues toward elucidating safe and effective pharmacotherapy for patients afflicted by this illness.
    10/2013; 2013:389537. DOI:10.1155/2013/389537
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