Download full-text


Available from: Oluyinka Oladele Opaleye, Apr 04, 2014
72 Reads
  • Source
    • "None of the pregnant women with history of previous blood transfusion were positive to HBsAg. This is not surprising as it is a national policy that all blood must be screened for HBsAg before transfusion in hospitals [32]. However, the significant association between HBsAg seropositivity in pregnant women in this study and history of previous HBV vaccination is in conformity with the findings by Alter and colleagues [36] who reported that no recognizable risk factor could be ascribed to 30% of cases of HBV infection in adults. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Background The transmission of the hepatitis B virus (HBV) is parenteral, sexual and perinatal. Prevention of vertical transmission of HBV is extremely important because HBV infection in early life usually results in a chronic carrier State. Methods A descriptive seroepidemiological study of hepatitis B virus and its effects on hematological parameters was investigated in pregnant women attending antenatal clinic of LAUTECH Teaching Hospital, Osogbo, Nigeria. 200 venous samples were subjected to full blood count and its sera were subjected to enzyme–linked immunosorbent assay for the detection of surface antigen of hepatitis B virus. Results Prevalence rate of 16.5% was obtained for hepatitis B surface antigen in pregnant women. The highest HBsAg prevalence rate recorded was 23.3% for pregnant women between aged 30–34 years while the lowest recorded was zero percent for those aged greater than 40 years. RBC, WBC, neutrophil, hemoglobin lymphocyte and platelet counts have no significant effects on HBsAg positivity of pregnant women (p = 0.801). There was no significant difference in HBsAg positivity in relation to maternal age, gravidity, gestational age, family type, level of education and occupation (p = 0.073). Among the potential risk factors, there was significant difference in HBsAg positivity in the pregnant women in relation to their history of HBV vaccination (p = 0.039). Conclusions We advocate universal free screening of pregnant women as the endemicity of HBV infections is thus being propagated.
    Virology Journal 12/2012; 9(1):317. DOI:10.1186/1743-422X-9-317 · 2.18 Impact Factor
  • Source
    • "In Nigeria, studies on the prevalence of HBsAg among blood donors have been documented. Opaleye et al. (2010) reported a prevalence rate of 5.4% among blood donors in Benin City, Nigeria. These showed that transfusion of HBV-infected blood was possible in Nigeria. "
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: This study aimed to determine the seroprevalence of anti-HCV antibodies among sexually active patients at UNAAB, Abeokuta, Nigeria. Samples of blood serum were collected from 132 subjects, stored and processed using standard laboratory procedures. DiaSpot® HCV-Ab Test strips (manufactured by DiaSpot Diagnostics, USA), Global® HCV-Ab Kit (manufactured by Global Diagnostics, USA) and IND® HCV-Ab kits (manufactured by IND R Diagnostica, USA) were used in a stepwise order for the detection of anti-HCV antibodies in the blood serum samples. The study showed that only 2(1.5%) of the subjects were positive for anti-HCV antibodies. Anti-HCV antibodies were detected only in males 2(3.1%). Anti-HCV antibodies were only detected in ages 15 to 29 years of age 2(1.7%) and none in ages 30 years and above. The study has further confirms the presence of anti-HCV antibodies in sexually active group (ages 15 to 29 years of age). HCV risk factors like age and gender appeared to be significantly associated with HCV antibody seropositivity (P<0.05), thus emphasizing the need for routine screening of blood for HCV in order to prevent their transmission among general population. The need for intensive health education to encourage abstinence among sexually active group is also emphasized.
Show more