HBV, HCV co-infection among blood donors in Nigeria.

Indian Journal of Pathology and Microbiology (Impact Factor: 0.64). 01/2010; 53(1):182-3. DOI: 10.4103/0377-4929.59229
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    ABSTRACT: This study aimed to determine the seroprevalence of anti-HCV antibodies among sexually active patients at UNAAB, Abeokuta, Nigeria. Samples of blood serum were collected from 132 subjects, stored and processed using standard laboratory procedures. DiaSpot® HCV-Ab Test strips (manufactured by DiaSpot Diagnostics, USA), Global® HCV-Ab Kit (manufactured by Global Diagnostics, USA) and IND® HCV-Ab kits (manufactured by IND R Diagnostica, USA) were used in a stepwise order for the detection of anti-HCV antibodies in the blood serum samples. The study showed that only 2(1.5%) of the subjects were positive for anti-HCV antibodies. Anti-HCV antibodies were detected only in males 2(3.1%). Anti-HCV antibodies were only detected in ages 15 to 29 years of age 2(1.7%) and none in ages 30 years and above. The study has further confirms the presence of anti-HCV antibodies in sexually active group (ages 15 to 29 years of age). HCV risk factors like age and gender appeared to be significantly associated with HCV antibody seropositivity (P<0.05), thus emphasizing the need for routine screening of blood for HCV in order to prevent their transmission among general population. The need for intensive health education to encourage abstinence among sexually active group is also emphasized.
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    ABSTRACT: Hepatitis B and C have been identified as major causes of Transfusion transmitted infections, in Nigeria. Our objective was to determine the prevalence of HBV and HCV in prospective blood donors in Abeokuta, Nigeria. 305 blood donors were screened for the presence of HBsAg and HCV using a rapid immunochromatographic kit (DiaSpot®). Demographic information information was also collected. Males constituted 96.4%, singles were the majority with 65%. Prevalence of HBsAg was 9.8%, HCV 1.3% and dual positivity 0.3%. Prevalence of HBsAg and HCV among males was 10.2% and 1.4%, while females recorded 0.0% for HCV and HBsAg. Dual positivity was recorded in a male (0.33%). Analysis of the study variables revealed that only educational status was statistically associated with positivity of HBsAg (χ(2) = 7.49, p = 0.02), HCV prevalence was highest in the illiterate group it was not statistically significant (P > 0.05). We report the prevalence rates of anti-HCV Ab and HBsAg in blood donors from Ogun State, Nigeria. Our results reveals higher rate of HBsAg and evidence of co-infection with both viruses, illiteracy was the only variable associated with HBV infection. We advocate for the inclusion of anti-HBc or HBeAg in donor screening in our environment.
    Journal of Immunoassay and Immunochemistry 03/2014; · 0.73 Impact Factor

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