Article

Antiobesity and hypolipidemic effects of polyphenol-rich longan (Dimocarpus longans Lour.) flower water extract in hypercaloric-dietary rats.

School of Health Diet and Industry Management, Chung Shan Medical University, Taichung 402, Taiwan.
Journal of Agricultural and Food Chemistry (impact factor: 2.82). 02/2010; 58(3):2020-7. DOI:10.1021/jf903355q
Source: PubMed

ABSTRACT Plenty of polyphenols, i.e. phenolic acids and flavonoids, were found in longan flower water extract (LFWE) through spectrophotometric and HPLC analyses. Antiobesity and hypolipidemic effects of polyphenol-rich longan flower water extract (LFWE) were investigated in this study. Eight male rats per group were assigned randomly to one of the following dietary groups: (1) normal-caloric diet and pure water (NCD + NDW); (2) hypercaloric diet and pure water (HCD + NDW); (3) HCD and 1.25% (w/v) LFWE (HCD + 1.25% LFWE); (4) HCD and 2.5% (w/v) LFWE (HCD + 2.5% LFWE) for 9 weeks. Body weight, size of epididymal fat, serum triglyceride level and atherogenic index, and hepatic lipids were decreased (p < 0.05) in HCD rats by drinking 2.5% LFWE which may result from downregulated (p < 0.05) pancreatic lipase activity, and sterol regulatory element binding protein-1c (SREBP-1c) and fatty acid synthase (FAS) gene expressions, as well as upregulated (p < 0.05) LDL receptor (LDLR) and peroxisome proliferator-activated-receptor-alpha (PPAR-alpha) gene expressions, and also increased (p < 0.05) fecal triglyceride excretions. Therefore, polyphenol-rich LFWE indeed characterizes antiobesity and hypolipidemic effects in vivo.

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    [show abstract] [hide abstract]
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Keywords

Antiobesity
 
Body weight
 
epididymal fat
 
fatty acid synthase
 
following dietary groups
 
HCD + NDW
 
HCD rats
 
hepatic lipids
 
LDLR
 
longan flower water
 
male rats
 
NCD + NDW
 
phenolic acids
 
polyphenol-rich longan flower water
 
polyphenols
 
PPAR-alpha
 
serum triglyceride level
 
sterol regulatory element binding protein-1c