Lenalidomide (Revlimid) combined with continuous oral cyclophosphamide (endoxan) and prednisone (REP) is effective in lenalidomide/dexamethasone-refractory myeloma

British Journal of Haematology (Impact Factor: 4.71). 01/2010; 148(2):335-7. DOI: 10.1111/j.1365-2141.2009.07931.x
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Available from: Monique Minnema, Sep 17, 2014
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    • "The MTD was 600 mg CY on days 1 and 8. Grade 3/4 hematological complications occurred in 26% of patients, grade 3/4 infections in 3%, with thromboembolic complications in 6% [15]. van de Donk et al. reported that grade 3/4 neutropenia was observed in 43% of patients and grade 3 infection and deep venous thrombosis were observed in 21% and 14%, respectively [16]. Although our patient had mild gastric discomfort and grade 3 neutropenia, the side effects were resolved when CY or lenalidomide was withheld. "
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