Article

Investigation of human papillomavirus DNA in colorectal carcinomas and adenomas.

Department of Pathology, Dr Lutfi Kirdar Kartal Training and Research Hospital, 34865 Cevizli/Istanbul, Turkey.
Medical Oncology (impact factor: 2.14). 03/2011; 28(1):127-32. DOI:10.1007/s12032-010-9416-4
Source: PubMed

ABSTRACT Human papillomavirus (HPV) has been considered to be an etiological agent for anogenital cancers, such as cervical cancer and possibly a subset of cancers of the aerodigestive tract. The aim of the study was to evaluate the presence of human papillomavirus DNA in colorectal carcinomas and adenomas. Formalin-fixed and paraffin-embedded archival tissue samples were used for DNA extraction. One hundred and six colorectal carcinomas and 62 adenomas were screened by nested polymerase chain reaction (PCR) for HPV DNA with a control group of 49 cervical tissues with invasive cervical carcinoma and cervical intraepithelial neoplasia (CIN). In the study group, we did not find HPV DNA positivity in any of all the colorectal carcinomas and adenomas. In the control group with cervical lesions, 34 out of 49 (69.4%) samples were positive for the HPV DNA. These results indicated that there was no correlation between HPV infection and colorectal carcinomas and adenomas.

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Keywords

49 cervical tissues
 
aerodigestive tract
 
anogenital cancers
 
cancers
 
cervical cancer
 
cervical intraepithelial neoplasia
 
colorectal carcinomas
 
control group
 
DNA extraction
 
etiological agent
 
Formalin-fixed
 
HPV DNA
 
HPV DNA positivity
 
Human papillomavirus
 
human papillomavirus DNA
 
invasive cervical carcinoma
 
nested polymerase chain reaction
 
paraffin-embedded archival tissue samples
 
study group