A comparison of three times vs. five times weekly narrowband ultraviolet B phototherapy for the treatment of chronic plaque psoriasis.
ABSTRACT Narrowband ultraviolet B (NB-UVB) phototherapy is an effective treatment for psoriasis.
To compare the effects of three and five times weekly NB-UVB phototherapy in the treatment of chronic plaque psoriasis. Methods: Sixty-five patients with chronic plaque psoriasis were allocated to receive three or five times weekly NB-UVB, starting at low dose.
Among the patients who completed the study, clearance was achieved in 18 out of 23 patients (78%) in the three times weekly group and in 15 out of 22 patients (68%) in the five times weekly group. The difference was not statistically significant (P=0.44). No statistically significant differences were found between the two groups in the number of treatments (P=0.95), cumulative UVB dose (P=0.51), and rate of side-effects. Length of the treatment period was significantly shorter in the five times weekly group (P<0.001). At the end of treatment, the mean psoriasis area and severity index score was lower in the three times weekly group (P=0.02).
We recommend three times weekly NB-UVB for chronic plaque psoriasis; however, the more rapid clearance of psoriasis with five times weekly phototherapy may justify using this method in some patients.
- SourceAvailable from: Prospero C. Naval
Conference Proceeding: PSORIASIS UV PHOTOTHERAPY DOSAGE OPTIMIZATION THROUGH A 3-DIMENSIONAL AGENT-BASED MODEL[show abstract] [hide abstract]
ABSTRACT: An agent-based model (ABM) was constructed to integrate dermatological data from literature on the interactions of the skin and immune system cells in psoriasis and study the conflicting roles of ultraviolet radiation (UVR) as a disease treatment and as a carcinogenic agent. Backed by clinical judgement from an expert dermatologist and validated with data available from literature, the model was subjected to various experimental scenarios which would be costly or even not feasible under clinical or laboratory settings. Lastly, the model was used to suggest possible therapeutic regimens by subjecting it to multi-objective evolutionary optimization using the Non-dominated Sorting Genetic Algorithm-II (NSGA-II) which is capable of dealing with the apparently conflicting aspects of the system. Results of the ABM-driven evolutionary optimization suggested some alternatives that are well-balanced in terms of the therapeutic and harmful effects even with adjunct treatments such topical corticosteroids or in the presence of certain constraints such as limited time for therapy and decreased patient tolerance to aggressive dosages.HNICEM 2011; 03/2011