Severe malaria is associated with a deficiency of von Willebrand factor cleaving protease, ADAMTS13.
ABSTRACT Severe falciparum malaria remains a major killer in tropical countries. Central in the pathophysiology is mechanical obstruction in the microcirculation caused by cytoadherence and sequestration of parasitized erythrocytes. However, the pathogenesis of many features complicating severe malaria, including coma, renal failure and thrombocytopenia, remains incompletely understood. These disease manifestations are also key features of thrombotic thrombocytopenic purpura, a life-threatening disease strongly associated with a deficiency of the von Willebrand factor (VWF) cleaving protease, ADAMTS13. We measured plasma ADAMTS13 activity, VWF antigen and VWF propeptide levels in 30 patients with severe falciparum malaria, 12 patients with uncomplicated falciparum malaria and 14 healthy Bangladeshi controls. In patients with severe malaria ADAMTS13 activity levels were markedly decreased in comparison to normal controls (mean [95%CI]: 23% [20-26] vs. 64% [55-72]) and VWF antigen and propeptide concentrations were significantly elevated (VWF antigen: 439% [396-481] vs. 64% [46-83]; VWF propeptide: 576% [481-671] vs. 69% [59-78]). In uncomplicated malaria VWF levels were also increased compared to healthy controls but ADAMTS13 activity was normal. The results suggest that decreased ADAMTS13 activity in combination with increased VWF concentrations may contribute to the complications in severe malaria.
- SourceAvailable from: François Sanchez[show abstract] [hide abstract]
ABSTRACT: We consider the propagation of few-cycle pulses (FCPs) in cubic nonlinear media exhibiting a “crystal-like” structure, beyond the slowly varying envelope approximation, taking into account the wave polarization. By using the reductive perturbation method we derive from the Maxwell–Bloch–Heisenberg equations, in the long-wave-approximation regime, a non-integrable complex modified Korteweg-de Vries equation describing the propagation of circularly polarized (CP) FCPs. By direct numerical simulations of the governing nonlinear partial differential equation we get robust CP FCPs and we show that the unstable ones decays into linearly polarized half-cycle pulses, whose polarization direction slowly rotates around the propagation axis.Optics Communications 02/2012; · 1.44 Impact Factor