Article

Engineered transaminopeptidase, aminolysin-S for catalysis of peptide bond formation to give linear and cyclic dipeptides by one-pot reaction.

Research Institute for Biological Sciences (RIBS), Okayama, 7549-1 Kibichuo-cho, Kaga-gun, Okayama 716-1241, Japan.
Chemical Communications (impact factor: 6.17). 01/2010; 46(4):580-2. DOI:10.1039/b914320c pp.580-2
Source: PubMed

ABSTRACT Aminopeptidase from Streptomyces thermocyaneoviolaceus NBRC14271 was engineered into transaminopeptidase and used to catalyze an aminolysis reaction to give linear and cyclic dipeptides from cost-effective substrates such as the ester derivatives of amino acids.

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Keywords

amino acids
 
aminolysis reaction
 
Aminopeptidase
 
cost-effective substrates
 
Streptomyces thermocyaneoviolaceus NBRC14271
 
transaminopeptidase