Article

[Pathophysiology of liver ischemia-reperfusion injury].

Departamento de Cirugía, Hospital Clínico San Carlos, Facultad de Medicina, Universidad Complutense, Madrid, España.
Cirugía Española (impact factor: 0.87). 04/2010; 87(4):202-9. DOI:10.1016/j.ciresp.2009.11.009 pp.202-9
Source: PubMed

ABSTRACT Hepatic ischemia-reperfusion injury is an underlying complication that occurs in clinical conditions such as hepatic resection surgery, liver transplantation and the states of shock. Such injury has classically been attributed to the joint deleterious action of both neutrophils and reactive oxygen species. However, there is increasing evidence that T lymphocytes are also key players in the acute reperfusion injury of diverse organs. They seem to act mainly by promoting the recruitment of inflammatory cells. The purpose of this review is to summarize the molecular and cellular mechanisms that participate in the pathophysiology of liver reperfusion injury.

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Keywords

acute reperfusion injury
 
cellular mechanisms
 
diverse organs
 
Hepatic ischemia-reperfusion injury
 
hepatic resection surgery
 
inflammatory cells
 
joint deleterious action
 
liver reperfusion injury
 
liver transplantation
 
molecular
 
reactive oxygen species
 
underlying complication
 

José Angel Ildefonso