Contact allergy to trimethyl-benzenepropanol (Majantol®)

National Allergy Research Centre, Department of Dermato-allergology, Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark.
Contact Dermatitis (Impact Factor: 3.75). 12/2009; 61(6):360-1. DOI: 10.1111/j.1600-0536.2009.01648.x
Source: PubMed
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  • Article: Majantol.
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    ABSTRACT: Majantol is a synthetic fragrance with an intensely floral, slightly fruity, and amber scent used in perfumes, cosmetics, and personal hygiene products. It has recently been identified as yet another fragrance contact allergen, with relatively high rates of sensitization. Majantol is not included in fragrance mix I or fragrance mix II, which are common patch-test screening chemicals for fragrance allergy. Moreover, because it is only a supplement to the North American series, there is a paucity of published data on the prevalence of contact allergy to this substance. Patch testing with Majantol could be useful in patients with suspected or proven contact allergy to fragrances; however, avoidance would be challenging, given that Majantol is unlikely to be listed specifically on the product label.
    Dermatitis 04/2011; 22(2):112-3. DOI:10.2310/6620.2011.10071 · 1.63 Impact Factor
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    ABSTRACT: Background Negative patch test results with fragrance allergy markers in the European baseline series do not always predict a negative reaction to individual fragrance substances.Objectives To determine the frequencies of positive test reactions to the 26 fragrance substances for which labelling is mandatory in the EU, and how effectively reactions to fragrance markers in the baseline series predict positive reactions to the fragrance substances that are labelled.Methods The records of 1951 eczema patients, routinely tested with the labelled fragrance substances and with an extended European baseline series in 2011 and 2012, were retrospectively reviewed.ResultsTwo hundred and eighty-one (14.4%) (71.2% females) reacted to one or more allergens from the labelled-fragrance substance series and/or a fragrance marker from the European baseline series. The allergens that were positive with the greatest frequencies were cinnamyl alcohol (48; 2.46%), Evernia furfuracea (44; 2.26%), and isoeugenol (40; 2.05%). Of the 203 patients who reacted to any of the 26 fragrances in the labelled-fragrance substance series, only 117 (57.6%) also reacted to a fragrance marker in the baseline series. One hundred and seven (52.7%) reacted to either fragrance mix I or fragrance mix II, 28 (13.8%) reacted to Myroxylon pereirae, and 13 (6.4%) reacted to hydroxyisohexyl 3-cyclohexene carboxaldehyde.Conclusions These findings confirm that the standard fragrance markers fail to identify patients with contact allergies to the 26 fragrances.
    Contact Dermatitis 05/2014; 70(5). DOI:10.1111/cod.12171 · 3.75 Impact Factor
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    ABSTRACT: Contact allergy to fragrances is common, and impairs quality of life, particularly in young women. To provide current results on the prevalences of sensitization to fragrance allergens used as markers in the baseline series of most European countries. Data of patients consecutively patch tested between 2009 and 2012 in 12 European countries with fragrance allergens contained in the baseline series were collected by the European Surveillance System on Contact Allergies network and descriptively analysed. Four departments used the TRUE Test® system. The 'basic markers' were tested on 51 477 [fragrance mix II (FM II)] to 57 123 [Myroxylon pereirae, balsam of Peru] patients, and yielded positive reactions as follows: fragrance mix I 6.9%, Myroxylon pereirae 5.4%, FM II 3.8%, colophonium 2.6%, and hydroxyisohexyl 3-cyclohexene carboxaldehyde 1.7%, with some regional differences. Prevalences with TRUE Test® allergens were lower. Additional fragrances were tested on 3643 (trimethylbenzenepropanol) to 14 071 (oil of turpentine) patients, and yielded between 2.6% (Cananga odorata) and 0.7% (trimethylbenzenepropanol) positive reactions. Contact allergy to fragrances is common throughout Europe, with regional variation probably being explained by patch test technique, and differences in exposure and referral patterns. The current basic markers of fragrance sensitivity in the baseline series should be supplemented with additional fragrance allergens. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
    Contact Dermatitis 06/2015; 73(3). DOI:10.1111/cod.12420 · 3.75 Impact Factor