Article

Soy consumption and colorectal cancer risk in humans: a meta-analysis.

USDA, ARS, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202-9034, USA.
Cancer Epidemiology Biomarkers &amp Prevention (impact factor: 4.12). 01/2010; 19(1):148-58. DOI:10.1158/1055-9965.EPI-09-0856 pp.148-58
Source: PubMed

ABSTRACT The purpose of the present study was to determine the relationship between soy consumption and colorectal cancer risk in humans by conducting a meta-analysis of available epidemiologic studies. We systematically reviewed publications obtained through a Medline literature search and identified four cohort and seven case-control studies on soy and colorectal cancer risk that met the inclusion criteria. We extracted the risk estimate (hazard ratio, relative risk, or odds ratio) of the highest and the lowest reported categories of intake from each study and conducted this analysis using a random-effects model. Our analysis did not find that soy consumption was associated with colorectal cancer risk [combined risk estimate, 0.90; 95% confidence interval (95% CI), 0.79-1.03] nor did the separate analyses on colon cancer (combined risk estimate, 0.88; 95% CI, 0.74-1.06) and rectal cancer (combined risk estimate, 0.88; 95% CI, 0.67-1.14). However, when separately analyzed on the basis of gender, we found that soy was associated with an approximately 21% reduction in colorectal cancer risk in women (combined risk estimate, 0.79; 95% CI, 0.65-0.97; P = 0.026), but not in men (combined risk estimate, 1.10; 95% CI, 0.90-1.33). Thus, consumption of soy foods may be associated with a reduction in colorectal cancer risk in women, but not in men.

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    Article: Flavonoide zur Krebsprävention im Darm
    Harald Hoensch, Elke Richling, Wolfgang Kruis, Wilhelm Kirch
    [show abstract] [hide abstract]
    ABSTRACT: Hintergrund: Da derzeit keine nachhaltigen und sicheren Möglichkeiten zur Prävention von Neoplasien, insbesondere beim kolorektalen Karzinom (KRK), bestehen, könnten wirksame, praktikable Strategien die Inzidenz dieser häufigen Krebsform vermindern. Es ist bekannt, dass diätetische Faktoren die Entstehung des KRK und seiner Vorstufen modifizieren. Dabei scheinen diätetische Interventionen mit sekundären Pflanzeninhaltsstoffen sehr erfolgversprechend. Methodik: Eine selektive Literaturrecherche in der Datenbank PubMed wurde unter Verwendung folgender Stichwörter durchgeführt: „flavonoids“, „cancer“, „therapy“, „colorectal cancer“ neben dem Stichwort „clinical query“. Des Weiteren wurden eigene therapeutische Ergebnisse aufgenommen und die Wertigkeit klinischer Studien verglichen. Ergebnisse: In-vitro- und In-vivo-Studien mit Tiermodellen, Zellkulturen und Zellbestandteilen haben ergeben, dass Flavonoide antimutagene und antikarzinogene Wirkungen entfalten. Verschiedene biologische und molekulare Endpunkte der Karzinogenese werden im Sinne einer Schutzwirkung beeinflusst. Isoflavonoide können in vitro proliferationsinduzierende Wirkungen bei Brustkrebszellen zeigen. Epidemiologische Studien (Kohorten-, Fall-Kontroll- und Querschnittsstudien) ergeben kein einheitliches Bild hinsichtlich einer präventiven Wirkung der Flavonoide. Systematische Reviews und Metaanalysen zeigen eine Schutzwirkung bestimmter Flavonoide (z.B. Epigallocatechingallat) bei Frühformen der Neoplasien (Adenomen). Schlussfolgerung: Flavonoide wirken antimutagen und antikarzinogen und könnten sich zur Prävention von bestimmten Krebsformen eignen, besonders bei adenomatösen Neoplasien im Intestinaltrakt. Eine relevante klinische Wirkung muss durch randomisierte, kontrollierte klinische Studien nachgewiesen werden. Background: Valid, sustained and safe clinical means of colorectal cancer prevention are still lacking, but they are urgently needed to lower the incidence of colorectal cancer. Dietary factors and phytochemicals such as flavonoids play an important role for prevention. Methods: A selective search of the literature using PubMed was performed with the following key words: flavonoids, cancer, therapy, colorectal cancer focused on clinical queries. Results of clinical studies including the authors’ own were compared. Results: In vivo and in vitro studies with animals, cell cultures and subcellular components provide ample evidence for antimutagenic and anticarcinogenic effects of flavonoids as shown for multiple biological and molecular endpoints. Isoflavonoids in vitro have been shown to induce proliferation of breast cancer cells. Epidemiologic trials (cohort, case-control and cross-sectional studies) yielded inconsistent results for flavonoid protection. Systematic reviews and meta-analyses support the protective role of tea flavonoids on adenoma incidence. An interventional pilot study with sustained flavonoid supplementation was shown to reduce the rate of neoplasia in patients with resected colorectal cancer. Conclusion: Selected flavonoids possess antimutagenic and anticarcinogenic properties and could reduce the incidence of colorectal neoplasias as shown in epidemiologic trials. Randomized controlled clinical studies with flavonoid intervention are necessary to provide evidence for their role in colorectal cancer prevention. Schlüsselwörter: Flavonoide-Darmkrebs-Prävention-Kolorektales Karzinom-Adenome Key Words: Flavonoids-Colorectal carcinoma-Prevention-Adenoma
    04/2012; 105(8):554-559.
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    Article: [Colorectal cancer prevention by flavonoids].
    Harald Hoensch, Elke Richling, Wolfgang Kruis, Wilhelm Kirch
    [show abstract] [hide abstract]
    ABSTRACT: Valid, sustained and safe clinical means of colorectal cancer prevention are still lacking, but they are urgently needed to lower the incidence of colorectal cancer. Dietary factors and phytochemicals such as flavonoids play an important role for prevention. A selective search of the literature using PubMed was performed with the following key words: flavonoids, cancer, therapy, colorectal cancer focused on clinical queries. Results of clinical studies including the authors' own were compared. In vivo and in vitro studies with animals, cell cultures and subcellular components provide ample evidence for antimutagenic and anticarcinogenic effects of flavonoids as shown for multiple biological and molecular endpoints. Isoflavonoids in vitro have been shown to induce proliferation of breast cancer cells. Epidemiologic trials (cohort, case-control and cross-sectional studies) yielded inconsistent results for flavonoid protection. Systematic reviews and meta-analyses support the protective role of tea flavonoids on adenoma incidence. An interventional pilot study with sustained flavonoid supplementation was shown to reduce the rate of neoplasia in patients with resected colorectal cancer. Selected flavonoids possess antimutagenic and anticarcinogenic properties and could reduce the incidence of colorectal neoplasias as shown in epidemiologic trials. Randomized controlled clinical studies with flavonoid intervention are necessary to provide evidence for their role in colorectal cancer prevention.
    Medizinische Klinik 08/2010; 105(8):554-9. · 0.34 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

21% reduction
 
95% confidence interval
 
analyzed
 
available epidemiologic studies
 
case-control studies
 
colon cancer
 
colorectal cancer risk
 
colorectal cancer risk [combined risk estimate
 
highest
 
humans
 
inclusion criteria
 
Medline literature search
 
meta-analysis
 
odds ratio
 
rectal cancer
 
separate analyses
 
soy
 
soy consumption
 
soy foods
 
women
 

Lin Yan