Design of a high-sensor count fibre optic manometry catheter for in-vivo colonic diagnostics.

CSIRO Materials Science and Engineering, PO Box 218, Lindfield, NSW 2070, Australia.
Optics Express (Impact Factor: 3.53). 12/2009; 17(25):22423-31. DOI: 10.1364/OE.17.022423
Source: PubMed

ABSTRACT The design of a fibre Bragg grating based manometry catheter for in-vivo diagnostics in the human colon is presented. The design is based on a device initially developed for use in the oesophagus, but in this instance, longer sensing lengths and increased flexibility were required to facilitate colonoscopic placement of the device and to allow access to the convoluted regions of this complex organ. The catheter design adopted allows the number of sensing regions to be increased to cover extended lengths of the colon whilst maintaining high flexibility and the close axial spacing necessary to accurately record pertinent features of peristalsis. Catheters with 72 sensing regions with an axial spacing of 1 cm have been assembled and used in-vivo to record peristaltic contractions in the human colon over a 24hr period. The close axial spacing of the pressure sensors has, for the first time, identified the complex nature of propagating sequences in both antegrade (towards the anus) and retrograde (away from the anus) directions in the colon. The potential to miss propagating sequences at wider sensor spacings is discussed and the resultant need for close axial spacing of sensors is proposed.

  • New Advances in Gastrointestinal Motility Research, Edited by L. K. Cheng, 01/2013: chapter Spatiotemporal mapping techniques for quantifying gut motility: pages 219-241; Dordrecht: Springer Science+Buisiness Media.
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    ABSTRACT: Background Until recently, investigations of the normal patterns of motility of the healthy human colon have been limited by the resolution of in vivo recording techniques.Methods We have used a new, high-resolution fiber-optic manometry system (72 sensors at 1-cm intervals) to record motor activity from colon in 10 healthy human subjects.Key ResultsIn the fasted colon, on the basis of rate and extent of propagation, four types of propagating motor pattern could be identified: (i) cyclic motor patterns (at 2–6/min); (ii) short single motor patterns; (iii) long single motor patterns; and (iv) occasional retrograde, slow motor patterns. For the most part, the cyclic and short single motor patterns propagated in a retrograde direction. Following a 700 kCal meal, a fifth motor pattern appeared; high-amplitude propagating sequences (HAPS) and there was large increase in retrograde cyclic motor patterns (5.6 ± 5.4/2 h vs 34.7 + 19.8/2 h; p < 0.001). The duration and amplitude of individual pressure events were significantly correlated. Discriminant and multivariate analysis of duration, gradient, and amplitude of the pressure events that made up propagating motor patterns distinguished clearly two types of pressure events: those belonging to HAPS and those belonging to all other propagating motor patterns.Conclusions & InferencesThis work provides the first comprehensive description of colonic motor patterns recorded by high-resolution manometry and demonstrates an abundance of retrograde propagating motor patterns. The propagating motor patterns appear to be generated by two independent sources, potentially indicating their neurogenic or myogenic origin.
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    ABSTRACT: For some critical applications, the location of fiber Bragg gratings (FBGs) in draw tower grating (DTG) arrays needs to be determined to sub-mm accuracy; for example, successful packaging of the FBGs in mm scale packages. The DTG manufacturing process leaves no external visible identification marks on the fiber, hence location needs to be determined prior to packaging. This work presents an automated fiber marking system that can accurately locate the positions of the FBGs within ±0.1 mm . The simple, low cost, and automated system avoids manual fiber handling and allows accurate packaging of the FBGs for sensing applications.
    Optical Engineering 08/2014; 53(8):084113. · 0.96 Impact Factor

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