Long-term effects of prenatal and infancy nurse home visitation on the life course of youths: 19-year follow-up of a randomized trial.
ABSTRACT To examine the effect of prenatal and infancy nurse home visitation on the life course development of 19-year-old youths whose mothers participated in the program.
Semirural community in New York.
Three hundred ten youths from the 400 families enrolled in the Elmira Nurse-Family Partnership program. Intervention Families received a mean of 9 home visits (range, 0-16) during pregnancy and 23 (range, 0-59) from birth through the child's second birthday.
Youth self-reports of educational achievement, reproductive behaviors, welfare use, and criminal involvement.
Relative to the comparison group, girls in the pregnancy and infancy nurse-visited group were less likely to have been arrested (10% vs 30%; relative risk [RR], 0.33; 95% confidence interval [CI], 0.13-0.82) and convicted (4% vs 20%; 0.20; 0.05-0.85) and had fewer lifetime arrests (mean: 0.10 vs 0.54; incidence RR [IRR], 0.18; 95% CI, 0.06-0.54) and convictions (0.04 vs 0.37; 0.11; 0.02-0.51). Nurse-visited girls born to unmarried and low-income mothers had fewer children (11% vs 30%; RR, 0.35; 95% CI, 0.12-1.02) and less Medicaid use (18% vs 45%; 0.40; 0.18-0.87) than their comparison group counterparts.
Prenatal and infancy home visitation reduced the proportion of girls entering the criminal justice system. For girls born to high-risk mothers, there were additional positive program effects consistent with results from earlier phases of this trial. There were few program effects for boys.
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ABSTRACT: Early interventions are a preferred method for addressing behavioral problems in high-risk children, but often have only modest effects. Identifying sources of variation in intervention effects can suggest means to improve efficiency. One potential source of such variation is the genome. We conducted a genetic analysis of the Fast Track randomized control trial, a 10-year-long intervention to prevent high-risk kindergarteners from developing adult externalizing problems including substance abuse and antisocial behavior. We tested whether variants of the glucocorticoid receptor gene NR3C1 were associated with differences in response to the Fast Track intervention. We found that in European-American children, a variant of NR3C1 identified by the single-nucleotide polymorphism rs10482672 was associated with increased risk for externalizing psychopathology in control group children and decreased risk for externalizing psychopathology in intervention group children. Variation in NR3C1 measured in this study was not associated with differential intervention response in African-American children. We discuss implications for efforts to prevent externalizing problems in high-risk children and for public policy in the genomic era.Journal of Policy Analysis and Management 01/2015; · 0.93 Impact Factor
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ABSTRACT: The objective of this methodology note is to examine perinatal program evaluation methods as they relate to the life course health development model (LCHD) and risk reduction for poor birth outcomes. We searched PubMed, CDC, ERIC, and a list from the Association of Maternal and Child Health Programs (AMCHP) to identify sources. We included reports from theory, methodology, program reports, and instruments, as well as reviews of Healthy Start Programs and home visiting. Because our review focused upon evaluation methods we did not include reports that described the Healthy Start Program. The LCHD model demonstrates the non-linear relationships among epigenetic factors and environmental interactions, intentionality or worldview within a values framework, health practices, and observed outcomes in a lifelong developmental health trajectory. The maternal epigenetic and social environment during fetal development sets the stage for the infant's lifelong developmental arc. The LCHD model provides a framework to study challenging maternal child health problems. Research that tracks the long term maternal-infant health developmental trajectory is facilitated by multiple, linked public record systems. Two instruments, the life skills progression instrument and the prenatal risk overview are theoretically consistent with the LCHD and can be adapted for local or population-based use. A figure is included to demonstrate a method of reducing interaction among variables by sample definition. Both in-place local programs and tests of best practices in community-based research are needed to reduce unacceptably high infant mortality. Studies that follow published reporting standards strengthen evidence.Maternal and child health journal. 01/2015;
- Rock Mechanics and Rock Engineering 11/2014; 47(6):2061-2073. · 1.56 Impact Factor
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This entry is our account of a study selected by Drug and Alcohol Findings as particularly relevant to improving
outcomes from drug or alcohol interventions in the UK. Unless indicated otherwise, permission is given to
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including the web address http://findings.org.uk. The original study was not published by Findings; click on the
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Long-term effects of prenatal and infancy nurse home
visitation on the life course of youths: 19-year follow -up of a
Eckenrode J ., Campa M., Luckey D.W . et al. Request reprint
Archives of Pediatric and Adolescent Medicine: 2010, 164( 1) , p. 9–15.
In their prevention themes British drug strategies place considerable weight on early
years parenting support; whatever else such efforts may achieve, this seminal US study
did not find any long-term effects on substance use.
Summary The issue addressed by this seminal US study was whether different degrees
of prenatal and early years support for first-time parents would affect the development of
their children in ways including their substance use. This report from the study follows up
the children to age 19, offering an unusually long-term perspective.
The featured report derives from the New York state site of the multi-site Nurse-Family
Partnership study. Between 1978 and 1980 researchers based at antenatal services
actively recruited young (under 19), poor or unmarried women in their first pregnancy.
Though other first-time mothers-to-be were allowed to join the study, 85% of the 400
who did join (500 were invited) were in at least one of these disadvantaged categories.
They were randomly allocated to four different kinds and degrees of support. The two
most basic simply offered to screen the child at age one and two for developmental
problems and refer them for help if needed with or without free transportation to relevant
services. Transportation made no difference to service use, so these groups were
combined. Additional to screening and transportation, a third group was regularly visited
at home by a nurse during pregnancy, on average nine times. A fourth group were
assigned to the full intervention which additionally entailed post-birth nurse home visits
(on average 23 times) up to the child's second birthday. Nurses aimed to improve
pregnancy outcomes and children's health and development by helping parents improve
their own health and provide more competent care, and to help families become
economically self-sufficient through family planning, completing education, and finding
work. To achieve these goals, nurses linked families with needed services and tried to
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involve fathers, family members, and friends in the pregnancy, birth, and early care of
At 19 years of age, 310 of the children – nearly 9 in 10 of those still alive, not adopted,
and not mentally disabled – completed a telephone interview which assessed their history
of arrests and convictions, delinquent and criminal behaviour, educational achievement,
pregnancies and births, use of welfare, and use of substances – specifically whether in
the past six months they had used illegal drugs or 'binge' drank over four drinks (over
56g alcohol or seven UK units) at one sitting. Of the 17 variables assessed, the only
statistically significant differences were fewer lifetime arrests and convictions among
children whose mothers had been visited both during pregnancy and infancy than those
not visited by the nurse but only screened for developmental problems.
These differences were due to the intervention's substantial impact on the female
children; among the boys there were essentially no differences. Supplementing these
analyses, it was shown that the intervention had delayed the age at which girls had been
(if at all) first arrested. In particular, the full intervention suppressed the incidence of
arrests for serious and violent crime by the girls and its impact on their arrests was
concentrated in the mid-teen years. There were also some indications of greater sexual
restraint and responsibility among full intervention children.
In respect of substance use, after adjusting for other influences, as defined by the study
52% of the screening-only children had recently used illegal drugs and 32% had 'binge'
drank, figures only marginally and non-significantly reduced to 49% and 28%
respectively among children whose mothers had been visited on average 31 times both
during pregnancy and infancy.
The authors' conclusions
The program produced enduring effects on girls' involvement with the criminal justice
system but, except for sex-related risks among youths born to high-risk women, there
were no other effects on the children's life course.
The English national drug strategy sees early years support for
disadvantaged or vulnerable families as an important way to reduce risks of a variety of
problems including substance use. Initiatives include preschool education and a
programme similar to that tested in the featured study – 'Family Nurse Partnerships' to
develop the parental capacity of mothers and fathers through intensive and structured
support from early pregnancy until the child is two years old. The Scottish drug strategy
also focuses on the development of an "early years framework" to build parenting and
family capacity to raise children less vulnerable to substance use problems among others.
By 2011 this approach had been incorporated in government-initiated proposed
legislation scheduled to be implemented in 2013.
Whatever their other positive effects, the evidence that such programmes can affect later
substance use is thin and made thinner yet by the featured report. Reviewers (1 2 3)
have identified the Nurse-Family Partnership study as one of just two pre-school
parenting programmes to have been shown to affect later substance use (details below).
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This lack of evidence could be because the outcomes assessed did not necessarily reflect
damaging forms of drug use which would be expected to be affected by a programme to
prevent dysfunctional development. In the featured study, over the past six months
getting drunk or trying cannabis once would have been enough to classify the young
adult as a binge drinker or illegal drug user, neither very unusual (as indicated by the
high proportions who met these criteria) or in themselves indicative of a suboptimal
These studies did not target substance using parents. Similar programmes which did
target these parents have not been shown to improve child development.
The positive results from the featured study emerged when the children were aged 15 and only among 'high
risk' families who were poor and/or where the mother was not married and who had been visited up to the
child's second birthday (children visited only during pregnancy were actually more likely to smoke, drink, use
drugs and to exhibit parent-observed substance-related problems). Compared to screening-only families,
children visited by nurses up to age two were less delinquent and anti-social including drinking less often (once
versus two to three times) in the past six months. There were also indications short of conventional levels of
statistical significance that they smoked fewer cigarettes and that their parents had noticed them engaging in
fewer problem behaviours related to drinking or drug use. In the featured report, around age 15 was when
impacts on the delinquency of the girls were at their height. It seems that whatever the effects on drinking and
other substance use at these ages, these did not persist to age 19, at least not in the form of a lower incidence
of heavy single occasion drinking or experience of illegal drugs.
The other such programme shown to have affected substance use was evaluated by the US High/Scope Perry
study (1 2 3). It recruited a small sample of poor black families and randomly assigned about half to a
preschool programme for children aged three and four. However, the intervention went well beyond the home
visits of the featured study. Delivered by qualified teachers with caseloads not exceeding eight children, it
involved daily pre-school classes lasting at least two and half hours each weekday featuring a participatory
education approach intended to support children's self-initiated learning, and the teachers visited the families at
home every week or every two weeks to forge an educationally-oriented partnership with the parents. Though
the (former) children were tracked up to age 40, beneficial effects on substance-related crime were focused in
the young adult years in the form of a much smaller proportion arrested for drug crimes than children in
families not offered a preschool programme.
Last revised 08 November 2011
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