Article

[Anti-Helicobacter pylori treatment in patients with idiopathic thrombocytopenic purpura].

Department of Clinic Laboratory Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 12/2009; 34(12):1251-4. pp.1251-4
Source: PubMed

ABSTRACT To observe the effect of anti-Helicobacter pylori (H.pylori) treatment on patients with idiopathic thrombocytopenic purpura (ITP) and its effect on blood platelet.
From April 2006 to April 2008, a total of 31 patients diagnosed as having ITP and H. pylori infection were collected. These patients were given standard antibiotic therapy for H. pylori eradication (omeprazole 20 mg, clarithromycin 0.5 g, and amoxicillin 1.0 g, twice per day for 1 week). The effect of anti-H. pylori treatment was analyzed, and the blood platelets were counted before the treatment and on day 7, 14, and 28 after the treatment.
Of the 31 ITP patients with H. pylori infection, 21 were cured and 10 were not effective, with the effective rate 67.74%. Blood platelet increased in the cured group but did not change in the no-effect group.
Anti-H. pylori treatment could increase the blood platelet, and H. pylori infection may be related to the reduction of blood platelet in ITP patients.

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Keywords

1 week
 
31 ITP patients
 
31 patients
 
amoxicillin 1.0 g
 
Anti-H
 
anti-Helicobacter pylori
 
blood platelet
 
blood platelets
 
clarithromycin 0.5 g
 
cured group
 
day 7
 
effective rate 67.74%. Blood platelet
 
H. pylori eradication
 
H. pylori infection
 
H.pylori
 
idiopathic thrombocytopenic purpura
 
no-effect group
 
omeprazole 20 mg
 
pylori treatment
 
standard antibiotic therapy