Cytotoxic effects of ultra-diluted remedies on breast cancer cells.
ABSTRACT The use of ultra-diluted natural products in the management of disease and treatment of cancer has generated a lot of interest and controversy. We conducted an in vitro study to determine if products prescribed by a clinic in India have any effect on breast cancer cell lines. We studied four ultra-diluted remedies (Carcinosin, Phytolacca, Conium and Thuja) against two human breast adenocarcinoma cell lines (MCF-7 and MDA-MB-231) and a cell line derived from immortalized normal human mammary epithelial cells (HMLE). The remedies exerted preferential cytotoxic effects against the two breast cancer cell lines, causing cell cycle delay/arrest and apoptosis. These effects were accompanied by altered expression of the cell cycle regulatory proteins, including downregulation of phosphorylated Rb and upregulation of the CDK inhibitor p27, which were likely responsible for the cell cycle delay/arrest as well as induction of the apoptotic cascade that manifested in the activation of caspase 7 and cleavage of PARP in the treated cells. The findings demonstrate biological activity of these natural products when presented at ultra-diluted doses. Further in-depth studies with additional cell lines and animal models are warranted to explore the clinical applicability of these agents.
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ABSTRACT: Finding safer and more effective treatments for specific cancers remains a significant challenge for integrative clinicians and researchers worldwide. One emerging strategy is the use of nanostructured forms of drugs, vaccines, traditional animal venoms, herbs, and nutraceutical agents in cancer treatment. The recent discovery of nanoparticles in traditional homeopathic medicines adds another point of convergence between modern nanomedicine and alternative interventional strategies. A way in which homeopathic remedies could initiate anticancer effects includes cell-to-cell signaling actions of both exogenous and endogenous (exosome) nanoparticles. The result can be a cascade of modulatory biological events with antiproliferative and pro-apoptotic effects. The Banerji Protocols reflect a multigenerational clinical system developed by homeopathic physicians in India who have treated thousands of patients with cancer. A number of homeopathic remedy sources from the Banerji Protocols (eg, Calcarea phosphorica; Carcinosin-tumor-derived breast cancer tissue prepared homeopathically) overlap those already under study in nonhomeopathic nanoparticle and nanovesicle tumor exosome cancer vaccine research. Past research on antineoplastic effects of nano forms of botanical extracts such as Phytolacca, Gelsemium, Hydrastis, Thuja, and Ruta as well as on homeopathic remedy potencies made from the same types of source materials suggests other important overlaps. The replicated finding of silica, silicon, and nano-silica release from agitation of liquids in glassware adds a proven nonspecific activator and amplifier of immunological effects. Taken together, the nanoparticulate research data and the Banerji Protocols for homeopathic remedies in cancer suggest a way forward for generating advances in cancer treatment with natural product-derived nanomedicines.Global advances in health and medicine : improving healthcare outcomes worldwide. 01/2014; 3(1):36-53.
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ABSTRACT: Homeopathy is a form of therapy based on the similarity (“similia similibus curantur”, like cures like), whose popularity is increasing but whose scientific basis is still under discussion. Starting from the premise that it is a “holistic” medicine, programmatically aimed at the whole person in its entirety and individuality, here we go through an overview of his history, basic concepts and scientific evidence. This therapy was founded by Samuel Hahnemann in the late 18th century, although similar concepts existed previously. It has spread around the world in the 19th century, in part because of its success in epidemics outbreaks, but declined during most of the 20th century. Its popularity was increased in the late 20th and early 21st century in many parts of the world and today stands the problem of its integration with conventional medicine. There are different schools of homeopathy. Homeopathy is controversial mainly because of its use of highly diluted medicines, but there is growing evidence that is not a mere placebo. There is a significant body of clinical research including randomized clinical trials suggesting that homeopathy has an effectiveness in curing many symptoms and in improving the quality of life of patients. Cohort studies, observational and economic have produced favorable results. Despite the long history of scientific controversy, homeopathy is an “anomaly” of modern medicine that deserves further investigation for its potential scientific and ethical merits.Journal of Medicine and the Person. 12/2014;
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ABSTRACT: Based on a common belief, herbal medicine with the least possible side effects should be the center of attention in cancer care; however, in many cases they have not been properly studied with reliable clinical trials in human subjects. In this review, it was attempted to identify the available evidence on the use and clinical effects of herbs in cancer care. The research consists of two major parts including immunomodulator and chemopreventive herbal compounds whose mechanism, biological response, anticancer element of extract and related benefits were completely studied. Also, the safety of herbal anticancer compounds was discussed. Although the use of herbal medicines in treating cancer shows less chemotherapy-induced, toxicity, more researches are required to reach their full therapeutic potentials.Iranian journal of cancer prevention. 01/2012; 5(3).