Article

Cytotoxic halogenated metabolites from the Brazilian red alga Laurencia catarinensis.

Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece.
Journal of Natural Products (impact factor: 3.13). 01/2010; 73(1):27-32. DOI:10.1021/np900627r pp.27-32
Source: PubMed

ABSTRACT Seven new (1-7) and seven previously reported (8-14) halogenated metabolites were isolated from the organic extract of the Brazilian red alga Laurencia catarinensis. The structure elucidation and the assignment of the relative configurations of the new natural products were based on detailed NMR and MS spectroscopic analyses, whereas the structure of metabolite 6 was confirmed by single-crystal X-ray diffraction analysis. The absolute configuration of metabolite 1 was determined using the modified Mosher's method. The in vitro cytotoxicity of compounds 1-14 was evaluated against HT29, MCF7, and A431 cell lines.

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Keywords

A431 cell lines
 
Brazilian red alga Laurencia catarinensis
 
metabolite 1
 
metabolite 6
 
metabolites
 
modified Mosher's method
 
MS spectroscopic analyses
 
new natural products
 
single-crystal X-ray diffraction analysis