Article

Depression in patients with Parkinson's disease and the associated features.

Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Journal of Huazhong University of Science and Technology (impact factor: 0.38). 12/2009; 29(6):725-8. DOI:10.1007/s11596-009-0610-6 pp.725-8
Source: PubMed

ABSTRACT The study was aimed to examine the prevalence of depression in patients with Parkinson's disease (PD) and identify its features. A total of 131 out-patients, diagnosed as having idiopathic PD in accordance with the United Kingdom Parkinson's Disease Society Brain Bank criteria, were interviewed with questionnaire and evaluated by Mini-Mental State Examination (MMSE), Unified Parkinson's Disease Rating Scale (UPDRS), Hohen &Yahr staging (H&Y staging) and Hamilton Rating Scale for Depression (HRSD). Patients were divided into three groups in terms of HRSD score: depression group, sub-threshold depression group and non-depression group. The clinical variables and symptom profiles were obtained and compared among the three groups. The results showed that 27 patients (20.6%) fell into the depression group, 71 (54.2%) into the sub-threshold depression group, and 33 (25.2%) into the non-depression group. There were no differences in age, gender or tremor score among the groups (P>0.05). Significant differences were found in duration of PD, UPDRS score, rigidity score and H&Y stage between the sub-threshold depression group (or the depression group) and the non-depression group (P<0.05). Moreover, the clinical variables in the subthreshold depression group had the trend of increasing with the severity of PD and their values were similar to those in the depression group. Anhedonia, feeling of incapability, sleep disturbance, gastrointestinal symptoms and depressive moods were most common in the depression group. And these symptoms also were more common in the other two groups. It is concluded that depression and sub-threshold depression are common in PD and share similar clinical features. Furthermore, subthreshold depression might be the prodrome of depression and may develop into depression as the condition progresses.

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    Article: Postural control in bipolar disorder: increased sway area and decreased dynamical complexity.
    Amanda R Bolbecker, S Lee Hong, Jerillyn S Kent, Mallory J Klaunig, Brian F O'Donnell, William P Hetrick
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    PLoS ONE 01/2011; 6(5):e19824. · 4.09 Impact Factor
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Keywords

131 out-patients
 
27 patients
 
condition progresses
 
gastrointestinal symptoms
 
Hamilton Rating Scale
 
HRSD score
 
idiopathic PD
 
Mini-Mental State Examination
 
non-depression group
 
P>0.05). Significant differences
 
rigidity score
 
sub-threshold depression
 
sub-threshold depression group
 
subthreshold depression
 
subthreshold depression group
 
three groups
 
tremor score
 
two groups
 
Unified Parkinson's Disease Rating Scale
 
UPDRS score
 

Jin Zheng