Article

Marked effect and steroid-sparing ability of anakinra on a patient with refractory adult-onset Still's disease.

Section of Allergy and Rheumatology, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku Tokyo, 104-8560, Japan.
Modern Rheumatology (impact factor: 1.58). 04/2010; 20(2):200-4. DOI:10.1007/s10165-009-0254-1 pp.200-4
Source: PubMed

ABSTRACT We report a case of refractory adult-onset Still's disease (AOSD) successfully controlled with anakinra, an interleukin-1 (IL-1) receptor antagonist. The patient was a 23-year-old Japanese woman with AOSD who could not be induced into remission despite of two courses of pulsed methylprednisolone followed by high-dose glucocorticoid administration in conjunction with high-dose intravenously administered gamma-globulin and methotrexate. To the best of our knowledge, this is the first case report in Japan of AOSD remission induced with anakinra.

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Keywords

23-year-old Japanese woman
 
courses
 
gamma-globulin
 
high-dose glucocorticoid administration
 
high-dose intravenously
 
IL-1
 
refractory adult-onset Still's disease