Lichen planopilaris treated with a peroxisome proliferator-activated receptor gamma agonist.

Departments of Dermatology, The Permanente Medical Group, Vallejo, California, USA.
Archives of dermatology (Impact Factor: 4.31). 12/2009; 145(12):1363-6. DOI: 10.1001/archdermatol.2009.283
Source: PubMed

ABSTRACT Primary cicatricial alopecias (PCAs), rare disorders that lead to permanent hair loss, have been poorly understood and are difficult to treat. Lichen planopilaris (LPP)is a prototypical PCA; patients often present with sudden onset of hair loss and clinically significant symptoms of itching, burning, and pain of the scalp. Examination reveals patchy alopecia or a more diffuse thinning of the scalp with characteristic perifollicular erythema and perifollicular scale at the margins of the areas of alopecia.Treatment typically includes use of antiinflammatory medications; although symptoms may improve,hair loss is often progressive.

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