6-n-Propylthiouracil sensitivity and obesity status among ethnically diverse children

USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Public Health Nutrition (Impact Factor: 2.68). 12/2009; 13(10):1587-92. DOI: 10.1017/S1368980009993004
Source: PubMed


To examine the relationship of 6-n-propylthiouracil (PROP) sensitivity to BMI while statistically controlling for demographic characteristics in two age groups of children: 9-10 years and 17-18 years (n 1551).
Cross-sectional design with a multi-ethnic (White, African-American, Hispanic, Other) sample of 813 children aged 9-10 years and 738 children aged 17-18 years. Children were recruited from local elementary and high schools with at least 30 % minority ethnic enrolment. Children's height, weight and waist circumference were measured along with their PROP taster status. PROP was measured using two paper discs, one impregnated with NaCl (1.0 mol/l) and the other with PROP solution (0.50 mmol/l).
A significant PROP sensitivity by socio-economic status (SES) interaction term (P = 0.010) was detected wherein supertasters had the largest BMI percentile and Z-score, but only among the group with highest SES.
The results suggest that other factors overwhelmed the influence of PROP sensitivity on adiposity in lower-SES groups. The percentage of variance accounted for by the interaction term was about 1 %. Thus, PROP supertasters had the largest BMI percentile and Z-score, but only among the highest-SES group.


Available from: Beverly J Tepper, Dec 18, 2013
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    • "Most population-based studies relating PROP-tasting to food and/or beverage selection have been conducted in Caucasian subjects residing in North America, Australia and Western Europe [19]–[23]–[28]–[40]–[41]. Notable exceptions are the study by Baranowski et al. [42] who studied White, Hispanic and Black children in the U.S.A. and the study by Mennella et al. [43] on African-American and non-Hispanic children and their mothers. Noteworthy works were also conducted in Asian populations [44]–[45]–[46]. "
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    PLoS ONE 03/2014; 9(3):e91716. DOI:10.1371/journal.pone.0091716 · 3.23 Impact Factor
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    • "Packets included information about the study, contact information for study staff, consent forms, and screening questionnaires regarding inclusion/exclusion criteria for parents to review. Eligible youth who returned signed consent forms from their parents (n=1690) enrolled in the first stage sample (Baranowski et al., 2010). A second stage sample (n = 843) was enrolled to efficiently collect detailed data on diet and PA. "
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