Descriptive epidemiology of cholangiocarcinoma in Italy.

Department of Clinical Medicine, Division of Gastroenterology, Polo Pontino, Sapienza University of Rome, Rome, Italy.
Digestive and Liver Disease (Impact Factor: 2.89). 12/2009; 42(7):490-5. DOI: 10.1016/j.dld.2009.10.009
Source: PubMed

ABSTRACT Very little data exist on the epidemiology of cholangiocarcinoma in Italy.
We focus on the descriptive epidemiology of cholangiocarcinoma in Italy.
Data on incidence were obtained from the Italian Association of Tumour Registries while mortality data were obtained from the Italian National Institute of Statistics.
A progressive increase of incidence with age was seen for extra-hepatic, intra-hepatic and not otherwise specified cholangiocarcinoma. Crude incidence rates were higher for extra-hepatic cholangiocarcinoma than those for intra-hepatic cholangiocarcinoma and in men compared to women. An increasing incidence trend was observed, from 1988 to 2005, for both extra-hepatic- and intra-hepatic cholangiocarcinoma with a 3-6% yearly increase and with a rate of increase higher for men than for women and for intra-hepatic- than for extra-hepatic cholangiocarcinoma. For intra-hepatic cholangiocarcinoma, the mortality rates progressively increased from 0.15 per million in 1980 to 5.9 per million in 2003, when mortality for this cancer surpassed extra-hepatic cholangiocarcinoma. Mortality rates for extra-hepatic cholangiocarcinoma showed an increasing trend from 1980 to 1994 but, in contrast to intra-hepatic cholangiocarcinoma, a stable or slightly decreasing trend from 1995 to 2003 was observed.
In Italy, cholangiocarcinoma showed a progressive increase in incidence and mortality in the last two decades mainly in intra-hepatic cholangiocarcinoma.

  • [Show abstract] [Hide abstract]
    ABSTRACT: Primary liver cancer consists of distinct subtypes with differing aetiology so it is valuable to study the incidence of these subtypes separately. This study aims to investigate time and socio-economic deprivation trends in the incidence of primary liver cancer subtypes in England, identifying the burden in the population.
    Journal of Evaluation in Clinical Practice 06/2014; · 1.58 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: This paper investigates the fault-tolerant control problem for a class of nonlinear systems with actuator faults, in which the control input is described by a nonlinear function with dead-zone. Using sliding mode and adaptive techniques, fault compensation method based fault-tolerant control law is designed to guarantee the stability of the faulty systems. The considered faults are unknown constant actuator faults with an unknown occurred time. In this paper, a fault tolerant control algorithm for nonlinear systems is proposed, and then the improved design is suggested. Finally, an example is given to show the effectiveness of the proposed method.
    2013 Chinese Automation Congress (CAC); 11/2013
  • [Show abstract] [Hide abstract]
    ABSTRACT: Cholangiocarcinoma (CCA) is a rare malignancy of the liver, arising from bile ducts. The incidence is increasing worldwide, but the prognosis has remained dismal and virtually unchanged in the past 30 years. Although several risk factors have been associated with the development of this cancer, none of them are normally identified in most patients. Diagnosis in advanced stages of the disease and limited therapeutic options contribute to poor survival rates. The recent analysis of genetic and epigenetic alterations occurring in CCA has shed new light in the understanding of the molecular mechanisms leading to the malignant transformation of biliary cells. Further studies in this direction may foster new diagnostic, prognostic and therapeutic approaches. This review provides a global overview of recent advances in CCA and describes the most important genetic mutations and epigenetic alterations so far reported in CCA.
    Annals of translational medicine. 10/2013; 1(3):28.