Article

"Label and go"--a fast and easy radiolabelling method for pellets.

Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine (impact factor: 1.09). 11/2009; 68(3):399-403. DOI:10.1016/j.apradiso.2009.11.040 pp.399-403
Source: PubMed

ABSTRACT For the development and process optimization of pharmaceutical equipment, it is important to investigate the underlying processes. Taking the fluidized bed technology as an example, the study of particle flow pattern and convection of the particles within the functional unity is essential for construction and process improvement. With positron emission particle tracking (PEPT) it is possible to study the real-time particle motion with radiolabelled particles. We established a fast and simple labelling technique with [(18)F]fluoride for pellets composed of Avicel and anion exchange resin. The uptake of activity ranged from 1.3% to 1.7% per mg and 8.6% to 16.3% per pellet. A specific binding of [(18)F]fluoride with increasing degree of anion exchange resin in the pellets could be observed.

0 0
 · 
0 Bookmarks
 · 
39 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

anion exchange resin
 
fast
 
functional unity
 
mg
 
particle flow pattern
 
particles
 
pharmaceutical equipment
 
process improvement
 
radiolabelled particles
 
real-time particle motion
 
simple labelling technique
 
specific binding
 
underlying processes
 
uptake