Article

A novel cytotoxic cerium complex: aquatrichloridobis(1,10-phenanthroline)cerium(III) (KP776). Synthesis, characterization, behavior in H2O, binding towards biomolecules, and antiproliferative activity.

University of Vienna, Institute of Inorganic Chemistry, Waehringer Strasse 42, A-1090 Vienna.
Chemistry & Biodiversity (impact factor: 1.8). 12/2009; 6(12):2153-65. DOI:10.1002/cbdv.200900011 pp.2153-65
Source: PubMed

ABSTRACT The lanthanide complex aquatrichloridobis(1,10-phenanthroline)cerium(III) [Ce(phen)2(H2O)Cl3] (KP776) was fully characterized by elemental analysis, IR-, and 1H- and 13C-NMR spectroscopy, as well as TG/DTA measurements, and its behavior in H2O, important for the application as a chemotherapeutic, was studied. In addition, the binding of KP776 to nucleotides and single serum proteins was investigated by capillary electrophoresis, whereas binding to proteins in human plasma was observed by ICP-MS. The compound shows promising anticancer properties in vitro: proliferation of human cancer cell lines is strongly inhibited with IC(50) values in the very low micromolar range.

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Keywords

binding
 
human cancer cell lines
 
human plasma
 
ICP-MS
 
lanthanide complex aquatrichloridobis(1,10-phenanthroline)cerium(III)
 
low micromolar range
 
promising anticancer properties
 
single serum proteins
 
vitro
 

Florian Biba