Article

Stem cell therapy improves the outcome of liver resection in cirrhotics.

General Surgery, Liver Research Unit, Stem Cell Research Division, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Journal of Gastrointestinal Cancer 12/2009; 41(1):17-23. DOI:10.1007/s12029-009-9092-9 pp.17-23
Source: PubMed

ABSTRACT Significant proportions of liver cirrhotic patients develop hepatocellular carcinoma and have to undergo hepatic resection. The compromised cirrhotic liver cannot withstand further removal of hepatic tissue, thus, leading to postoperative complication and death.
In this study, we enrolled 20 patients having liver cirrhosis with hepatocellular carcinoma and randomly assigned them into two groups to receive autologous stem cells or placebo.
After 3 weeks, all participants underwent liver resection and were followed for 12 weeks postoperative. We observed that the group receiving preoperative stem cell therapy had shown a significant improvement in all parameters of liver function and had no postoperative complications compared to the group treated with placebo, which showed no improvement in liver parameters and had postoperative complications.
In conclusion, autologous stem cell therapy can improve the surgical outcome in cirrhotic livers and should be considered as an adjuvant treatment in such patients undergoing hepatic resection.

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Keywords

12 weeks postoperative
 
20 patients
 
3 weeks
 
adjuvant treatment
 
autologous
 
cell therapy
 
cirrhotic livers
 
compromised cirrhotic liver
 
hepatocellular carcinoma
 
liver cirrhotic patients
 
liver function
 
participants
 
patients undergoing hepatic resection
 
postoperative complication
 
postoperative complications
 
randomly
 
Significant proportions
 
surgical outcome