Lifestyle management improves quality of life and depression in overweight and obese women with polycystic ovary syndrome
ABSTRACT To assess the impact of adding exercise to dietary restriction on depressive symptoms and health-related quality of life (HRQOL) in women with polycystic ovary syndrome (PCOS).
Analysis of depression and quality of life outcomes from a randomized, controlled prospective clinical intervention that evaluated the effects on a range of health outcomes in women with PCOS.
Clinical research unit.
One hundred four overweight/obese PCOS women (aged 29.3 ± 0.7 years; body mass index [BMI] 36.1 ± 0.5 kg/m(2)).
Randomized to one of three 20-week lifestyle programs: diet only, diet and aerobic exercise, or diet and combined aerobic-resistance exercise.
Depression and PCOS-specific HRQOL.
Forty-nine women completed the intervention (diet only = 14, diet and aerobic exercise = 15, diet and combined aerobic-resistance exercise = 20). By week 20 all groups achieved weight loss and had improvements in depression and PCOS-specific HRQOL scores, except for body hair domain score. There was no difference between treatments for all outcomes.
This study demonstrated that dietary restriction alone and combined with exercise had similar benefits for improving depression and HRQOL scores in overweight and obese women with PCOS.
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ABSTRACT: Polycystic Ovarian Syndrome (PCOS) is a common female endocrine disorder challenging feminine identity which is likely to impact their quality of life. The aim of this study was to evaluate the effect of yoga on PCOS specific quality of life in adolescent girls with PCOS. Ninety adolescent (15–18 years) girls from a residential college in Andhra Pradesh, who satisfied the Rotterdam criteria, were randomized into two groups. The yoga group (n = 37) practiced a holistic yoga module while the control group (n = 35) practiced a matching set of physical exercises (1 h/day, for 12 weeks). PCOS specific quality of life was measured at inclusion and after 12 weeks. Mann-Whitney on difference score showed that the changes in all domains were significantly different between the two groups (p < 0.05) except for infertility (p = 0.675). Wilcoxn signed ranks test showed yoga group observed greater improvement in emotional disturbances (effect size; Y:1.52, E: 0.72), body hair (effect size; Y: 1.02, E: 0.32), weight (effect size; Y: 0.96, E: 0.33) and menstrual problem (effect size; Y: 1.24, E: 0.64) domain as compared to the exercise group. Yoga program for 12 weeks is significantly better than physical exercise in improving PCOS quality of life in adolescent girls with PCOS.Applied Research in Quality of Life 09/2012; 8(3). DOI:10.1007/s11482-012-9191-9 · 0.74 Impact Factor
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ABSTRACT: Numerous concepts and competing interests have always confronted and pushed studies of symbiosis and cell evolution to the margins of science.They include emphasis on the disease-causing nature of microbes, and on conflict and competition between species; nucleocentric views of heredity, and gene-centred views of evolution.The synthetic and interdisciplinary nature of studies of symbiosis and cell evolution defied ever-increasing specialization in the life sciences such that biologists were often unwilling to assess them.The study of organelle origins also struggled under the weight of its speculative nature.Only in recent years have some of these difficulties been over-come.04/1995; 145(s 3–4). DOI:10.1016/S0003-9365(11)80321-0
Conference Paper: Wide bandwidth InP DHBT technology utilizing dielectric sidewall spacers[Show abstract] [Hide abstract]
ABSTRACT: We report device results from a wide bandwidth InP mesa-DHBT technology. In an effort to improve the manufacturability of submicron devices, the self-aligned base emitter junction is formed using dielectric sidewall spacers and a refractory base metal stack. Device performance has been optimized for high-speed digital and mixed-signal circuit applications. An HBT with emitter junctions dimensions of 0.7 × 3.0 μm<sup>2</sup> exhibited peak f<sub>τ</sub> and f<sub>max</sub> values of 292 GHz, and 314 GHz, respectively, at J<sub>E</sub> = 6 mA/μm<sup>2</sup> and V<sub>CB</sub> = 0.4 V. Importantly for digital logic circuits, the device had a low collector-base capacitance (C<sub>cb</sub> = 6.4 fF) resulting in a low collector-base capacitance to collector current ratio (C<sub>cb</sub>/Ic ∼ 0.5 psec/V).Indium Phosphide and Related Materials, 2004. 16th IPRM. 2004 International Conference on; 07/2004