Article

A generalized model of maximizing the sensitivity in intensity-interrogation surface plasmon resonance biosensors.

Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan, R.O.C.
Optics Express (impact factor: 3.59). 11/2009; 17(23):20771-6. pp.20771-6
Source: PubMed

ABSTRACT Intensity interrogation of surface plasmon resonance (IISPR) biosensors possesses the greatest sensitivity beyond other interrogations and is operated at a fixed incident angle to enable real-time analysis without time delay, so that it promises excellent performance in biological/chemical detection and SPR imaging systems. Here we provide a general model to describe its sensitivity based on Lorentz equation and unveil the relation between the sensitivity and the metal thickness. This model presents the dependency between sensitivity and metal thickness, and the optimal thickness of gold layers to maximize the sensitivity in our experiment is 53 nm that agrees well in both measurement and simulation. This general model can be further applied in other intensity-interrogation SPR configurations as a design rule for sensing and imaging applications.

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Keywords

biological/chemical detection
 
fixed incident angle
 
general model
 
IISPR
 
imaging applications
 
intensity-interrogation SPR configurations
 
interrogations
 
Lorentz equation
 
metal thickness
 
model presents
 
real-time analysis
 
SPR imaging systems
 
surface plasmon resonance
 
time delay
 

Chung-Tien Li